Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).


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PMID (PMCID)
29694313
 OTHER
Paget's disease of the male breast: case report and a point of view from actual literature.
Vergine M, Musella A, Gulotta E, Frusone F, De Luca A, Maceli F, Libia A, Benedetti Panici P, Monti M.
G Chir. 2018;39(2):114-117.
Histo-pathological examination revealed "invasive ductal carcinoma of the breast, associated with a small component of in situ ductal carcinoma and Paget's disease of the nipple with superficial ulceration".
29694313
 OTHER
Paget's disease of the male breast: case report and a point of view from actual literature.
Vergine M, Musella A, Gulotta E, Frusone F, De Luca A, Maceli F, Libia A, Benedetti Panici P, Monti M.
G Chir. 2018;39(2):114-117.
Histo-pathological examination revealed "invasive ductal carcinoma of the breast, associated with a small component of in situ ductal carcinoma and Paget's disease of the nipple with superficial ulceration".
30110525
 FEMALE Middle Aged
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast.
Tjarks BJ, Kerkvliet AM, Jassim AD.
S D Med. 2018;71(8):350-353.
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast.
30110525
 FEMALE Middle Aged
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast.
Tjarks BJ, Kerkvliet AM, Jassim AD.
S D Med. 2018;71(8):350-353.
Clinically, the differential diagnosis included Paget disease of the breast, squamous cell carcinoma, and sebaceous carcinoma.
23031371
 MALE
Extramammary Paget disease: Immunohistochemistry is critical to distinguish potential mimickers.
Wang EC, Kwah YC, Tan WP, Lee JS, Tan SH.
Dermatol Online J. 2012;18(9):4.
Extra-mammary Paget disease (EMPD) is a rare intra-epithelial carcinoma that is usually found on the apocrine-rich skin of the perineum.
21768603
 MIXED_SAMPLE
Intraepidermal glandular carcinoma of the nipple (mammary Paget-like disease) in 2 dogs.
Ramirez GA, Suarez-Bonnet A, Altimira J, Espinosa-de-los-Monteros A, Garcia-Gonzalez B, Vilafranca M.
Vet Pathol. 2012;49(4):612-5.
The purpose of this article is to present 2 cases of intraepidermal adenocarcinoma that resembled human mammary Paget disease, histologically and immunohistochemically, in dogs with underlying mammary carcinoma.
21768603
 MIXED_SAMPLE
Intraepidermal glandular carcinoma of the nipple (mammary Paget-like disease) in 2 dogs.
Ramirez GA, Suarez-Bonnet A, Altimira J, Espinosa-de-los-Monteros A, Garcia-Gonzalez B, Vilafranca M.
Vet Pathol. 2012;49(4):612-5.
Mammary Paget disease, characterized by diffuse infiltration of the nipple and areolar epidermis by carcinoma cells, develops in 1% to 3% of human mammary carcinomas.
21768603
 MIXED_SAMPLE
Intraepidermal glandular carcinoma of the nipple (mammary Paget-like disease) in 2 dogs.
Ramirez GA, Suarez-Bonnet A, Altimira J, Espinosa-de-los-Monteros A, Garcia-Gonzalez B, Vilafranca M.
Vet Pathol. 2012;49(4):612-5.
Mammary Paget disease, characterized by diffuse infiltration of the nipple and areolar epidermis by carcinoma cells, develops in 1% to 3% of human mammary carcinomas.
22895267
 FEMALE Adult
Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast.
Duan X, Sneige N, Gullett AE, Prieto VG, Resetkova E, Andino LM, Wu Y, Gilcrease MZ, Bedrosian I, Dawood S, Arun B, Albarracin CT.
Am J Surg Pathol. 2012;36(9):1353-8.
Mammary Paget disease (MPD) is considered an intraepidermal manifestation of an underlying mammary carcinoma.
21587034
 FEMALE Middle Aged
Pigmented paget disease of the breast nipple with underlying infiltrating carcinoma: a case report and review of the literature.
Soler T, Lerin A, Serrano T, Masferrer E, Garcia-Tejedor A, Condom E.
Am J Dermatopathol. 2011;33(5):e54-7.
Pigmented paget disease of the breast nipple with underlying infiltrating carcinoma: a case report and review of the literature.
18417683
 FEMALE Middle Aged
Cystic hypersecretory carcinoma of the breast with paget disease of the nipple: a diagnostic challenge.
Sahoo S, Gopal P, Roland L, Pile N.
Int J Surg Pathol. 2008;16(2):208-12.
A left simple mastectomy showed a large multicystic lesion occupying most of the lower quadrants by a cystic hypersecretory carcinoma and Paget disease of the nipple.
18417683
 FEMALE Middle Aged
Cystic hypersecretory carcinoma of the breast with paget disease of the nipple: a diagnostic challenge.
Sahoo S, Gopal P, Roland L, Pile N.
Int J Surg Pathol. 2008;16(2):208-12.
Cystic hypersecretory carcinoma of the breast with paget disease of the nipple: a diagnostic challenge.
17083907
 FEMALE Middle Aged
Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign).
Shamsadini S, Wadji MB, Shamsadini A.
Dermatol Online J. 2006;12(6):27.
We report a patient with Paget disease of the nipple and intraductal carcinoma who presented with ipsilateral, eruptive grouped seborrheic keratoses of the areola and nipple of the breast.
12140433
 FEMALE Adult
Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.
Requena L, Sangueza M, Sangueza OP, Kutzner H.
Am J Dermatopathol. 2002;24(3):189-98.
Two cases of pigmented mammary Paget disease and all cases of pigmented epidermotropic metastatic breast carcinoma showed the proliferation of dendritic melanocytes arranged as solitary units along the dermoepidermal junction and intermingled with the neoplastic cells of the mammary carcinoma in the superficial dermis.
11906447
 FEMALE
Ductal eccrine carcinoma presenting as a Paget's disease-like lesion of the breast.
Park BW, Kim SI, Lee KS, Yang WI.
Breast J. 2001;7(5):358-62.
A skin biopsy done under the clinical impression of Paget's disease of the nipple was initially misinterpreted as infiltrating ductal carcinoma, and a subsequent modified radical mastectomy revealed DEC exclusively confined to the nipple with perinodal tumor metastasis in one of the axillary lymph nodes.
7731933
 FEMALE
Paget's disease of the nipple and angiosarcoma of the breast following excision and radiation therapy for carcinoma of the breast.
Joshi MG, Crosson AW, Tahan SR.
Mod Pathol. 1995;8(1):1-4.
Paget's disease of the nipple and angiosarcoma of the breast following excision and radiation therapy for carcinoma of the breast.
2015924
 FEMALE Middle Aged
Florid papillomatosis of the nipple: a clinico-pathological surgical problem.
Scott P, Kissin MW, Collins C, Webb AJ.
Eur J Surg Oncol. 1991;17(2):211-3.
Adenoma or florid papillomatosis of the nipple is a rare, benign condition which resembles the clinical appearances of Paget's disease of the nipple and the histological appearances of papillary carcinoma of the breast.
2544464
 FEMALE
Paget's disease of the nipple occurring after wide local excision and radiotherapy for carcinoma of the breast.
Menzies D, Barr L, Ellis H.
Eur J Surg Oncol. 1989;15(3):271-3.
Paget's disease of the nipple occurring after wide local excision and radiotherapy for carcinoma of the breast.
3004315
 FEMALE Adult
Paget's disease of the nipple after subcutaneous mastectomy for cancer with primary reconstruction.
Shearman CP, Watts GT.
Ann R Coll Surg Engl. 1986;68(1):17-8.
Three cases of Paget's disease of the nipple are presented occurring in women treated for carcinoma of the breast with subcutaneous mastectomy and primary silicone reconstruction.
6280570
 FEMALE
[Associated Paget's disease of the vulva and of the nipple in the same patient: pathology with ultrastructural study (author's transl)].
Fetissoff F, Arbeille-Brassart B, Lansac J, Sam-Giao M, Granger M, Lorette G.
Ann Dermatol Venereol. 1982;109(1):43-50.
Paget's disease of the nipple is associated with an intraductal carcinoma (cribriform type).