Evans syndrome

A rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology.

Hemolytic anemia

A type of anemia caused by premature destruction of red blood cells (hemolysis).


Total: 17

                      


(per page)
PMID (PMCID)
30733882
OTHER
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.
Suzuki H, Yamanoi K, Ogura J, Hirayama T, Yasumoto K, Shitanaka S, Inayama Y, Sakai M, Ohara T, Suginami K.
Case Rep Obstet Gynecol. 2019;2019:2093612.
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.
29531655
(5841940)
OTHER
Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.
Zikidou P, Grapsa A, Bezirgiannidou Z, Chatzimichael A, Mantadakis E.
Mediterr J Hematol Infect Dis. 2018;10(1):e2018018.
Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.
26787583
FEMALE Adult
Evans syndrome and its link with systemic lupus erythematosus.
Mendonca S, Srivastava S, Kapoor R, Gupta D, Gupta P, Sharma ML.
Saudi J Kidney Dis Transpl. 2016;27(1):147-9.
Here, we describe a case of secondary Evans syndrome with severe hemolytic anemia leading to acute kidney injury and recovery thereafter only to develop lupus nephritis a few months later.
28292089
(5325491)
MALE Middle Aged
Multiple myeloma associated with an Evan's syndrome.
Bechir A, Haifa R, Nesrine BS, Emna B, Senda M, Asma A, Amina BB, Mrabet S, Yosra BY, Mondher K, Abderrahim K.
Pan Afr Med J. 2016;25:127.
Here, we report one MM case complicated by Evans syndrome (Autoimmun hemolytic anemia (AIHA) associated with thrombocytopenia).
27835759
(5233712)
MIXED_SAMPLE Adult
Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects.
Azevedo RS, Araujo MT, Martins Filho AJ, Oliveira CS, Nunes BT, Cruz AC, Nascimento AG, Medeiros RC, Caldas CA, Araujo FC, Quaresma JA, Vasconcelos BC, Queiroz MG, da Rosa ES, Henriques DF, Silva EV, Chiang JO, Martins LC, Medeiros DB, Lima JA, Nunes MR, Cardoso JF, Silva SP, Shi PY, Tesh RB, Rodrigues SG, Vasconcelos PF.
J Clin Virol. 2016;85:56-64.
A blood sample taken on the seventh day of her illness was positive RT-PCR for ZIKV RNA and research in the serum was positive for antinuclear factor fine speckled (1/640), suggesting Evans syndrome (hemolytic anemia an autoimmune disorder with immune thrombocytopenic purpura) secondary to ZIKV infection.
21772952
(3133497)
OTHER
Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome.
Farruggia P, Macaluso A, Tropia S, Genova S, Paolicchi O, Di Marco F, D'Angelo P.
Pediatr Rep. 2011;3(2):e15.
Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia.
18363174
FEMALE Infant
Pulmonary hypertension in children with Evans syndrome.
Connor P, Veys P, Amrolia P, Haworth S, Ashworth M, Moledina S.
Pediatr Hematol Oncol. 2008;25(2):93-8.
The authors speculate that the pulmonary hypertension was caused by the underlying immune dysregulation and hemolysis and that Evans syndrome joins the list of other hemolytic anemias that cause pulmonary hypertension, such as sickle cell disease, thalassemia, and paroxysmal nocturnal hemoglobinuria.
15128425
MALE Infant
Fatal Evans' syndrome after matched unrelated donor transplantation for hyper-IgM syndrome.
Urban C, Benesch M, Sovinz P, Schwinger W, Lackner H.
Eur J Haematol. 2004;72(6):444-7.
Ten months following SCT he presented with severe hemolytic anemia and thrombocytopenia (Evans' syndrome).
15326255
MALE Middle Aged
Sustained remission of CIDP associated with Evans syndrome.
Knecht H, Baumberger M, Tobon A, Steck A.
Neurology. 2004;63(4):730-2.
A patient with chronic inflammatory demyelinating polyneuropathy (CIDP) developed Evans syndrome (hemolytic anemia/thrombocytopenia) 17 months after onset of symptoms despite different immunomodulatory treatments.
15327386
MALE Child
Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS).
Licht C, Stapenhorst L, Simon T, Budde U, Schneppenheim R, Hoppe B.
Kidney Int. 2004;66(3):955-8.
We report a patient who was initially diagnosed with Evans syndrome (hemolytic anemia and autoimmune thrombocytopenia) as infant.
11921021
MALE Middle Aged
Hepatosplenic gammadelta T-cell lymphoma presenting with immune-mediated thrombocytopenia and hemolytic anemia (Evans' syndrome).
Motta G, Vianello F, Menin C, De Nicolo A, Agata S, Altavilla G, Pietrogrande F, Girolami A.
Am J Hematol. 2002;69(4):272-6.
Hepatosplenic gammadelta T-cell lymphoma presenting with immune-mediated thrombocytopenia and hemolytic anemia (Evans' syndrome).
12540008
FEMALE Adult
Intra-abdominal abscess caused by Listeria monocytogenes in a patient with acquired hemolytic anemia and thrombocytopenia.
Sile H, Norwood J.
South Med J. 2002;95(11):1350-2.
We report a case of an intra-abdominal abscess caused by Listeria monocytogenes in a postoperative patient with Evans syndrome (acquired hemolytic anemia and thrombocytopenia).
11979754
MALE Middle Aged
[Development of overt hemolytic anemia after splenectomy for thrombocytopenia in Evans syndrome with negative Coombs test].
Nakamura Y, Arai Y, Nakamura F, Maki K, Aoyagi A, Saito K, Mitani K.
Rinsho Ketsueki. 2002;43(3):204-6.
[Development of overt hemolytic anemia after splenectomy for thrombocytopenia in Evans syndrome with negative Coombs test].
11910874
FEMALE Middle Aged
[Fatal bleeding complications caused by Evans syndrome (autoimmune thrombocytopenia and hemolytic anemia) and type II autoimmune hepatitis in a 56-year-old patient].
Zugmaier G, Jager R, Neubauer A, Mennel HD, Knabbe C, Dienes HP.
Med Klin (Munich). 2002;97(2):88-90.
[Fatal bleeding complications caused by Evans syndrome (autoimmune thrombocytopenia and hemolytic anemia) and type II autoimmune hepatitis in a 56-year-old patient].
11339180
FEMALE Adult
[Evans syndrome, pregnancy, and preeclampsia].
Hernandez-Salazar E, Martinez-Abundis CE, Gonzalez-Ortiz CM.
Ginecol Obstet Mex. 2001;69:88-92.
Evans' syndrome is an unusual illness of autoimmune etiology, characterized by thrombocytopenia and hemolytic anemia.
10455373
MALE Infant
Immune thrombocytopenia after umbilical cord progenitor cell transplant: response to vincristine.
Dovat S, Roberts RL, Wakim M, Stiehm ER, Feig SA.
Bone Marrow Transplant. 1999;24(3):321-3.
Four months following the transplant, he developed immune thrombocytopenia with hemolytic anemia (Evans syndrome).
2511722
FEMALE
Hemophagocytic syndrome causing complete bone marrow failure. Report of an extreme case of a reactive histiocytic disorder.
de la Serna FJ, Lopez JI, Garcia-Marcilla A, Ortiz-Conde MC, Mestre MJ.
Acta Haematol. 1989;82(4):197-200.
We report a case in association with immune thrombocytopenia and hemolytic anemia (Evans' syndrome).