Evans syndrome

A rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology.

Anemia

A reduction in erythrocytes volume or hemoglobin concentration.

Total: 9

(per page)

PMID (PMCID)
30631001	FEMALE	Adult
	Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.
	Darmawan G, Hamijoyo L, Oehadian A, Bandiara R, Amalia L. Acta Med Indones. 2018;50(4):343-345.
	One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy.
29531655 (5841940)	OTHER
	Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.
	Zikidou P, Grapsa A, Bezirgiannidou Z, Chatzimichael A, Mantadakis E. Mediterr J Hematol Infect Dis. 2018;10(1):e2018018.
	We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia.
30620809	FEMALE
	[A case of Evans syndrome in a long-term hemodialysis patient].
	Ishikawa M, Hirose C, Zhang J, Hori K, Oyama S, Sugano K, Ohno A, Tomita K. Nihon Jinzo Gakkai Shi. 2017;59(4):578-583.
	Differential diagnosis for anemia revealed that she had newly developed Evans syndrome, which is the complication of autoimmune hemolytic ane- mia (AIHA) and idiopathic thrombocytopenic purpura(ITP).
27195703	MALE
	Coombs Positive Thrombotic Thrombocytopenic Purpura in a Male Pediatric Patient: An Urgent Diagnostic Challenge.
	Zenno A, Richardson M. Pediatr Blood Cancer. 2016;63(10):1860-2.
	We report a case of an adolescent with thrombocytopenia and Coombs positive anemia, diagnosed with Evans syndrome, but ultimately found to have TTP.
22446656	FEMALE	Adult
	Successful rituximab therapy in refractory autoimmune hepatitis and Evans syndrome.
	Carey EJ, Somaratne K, Rakela J. Rev Med Chil. 2011;139(11):1484-7.
	One month later the patient was hospitalized for sudden onset of anemia and thrombocytopenia, suggestive of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura consistent with Evans syndrome.
18709985	MALE	Middle Aged
	[Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia].
	Kakinoki Y, Nagase M, Okada K, Chiba K, Fukuhara T, Miyake T. Rinsho Ketsueki. 2008;49(7):516-20.
	Although thrombocytopenia (Evans syndrome) subsequently appeared, corticosteroid was extremely effective for both anemia and thrombocytopenia.
17179698 (2721940)	FEMALE	Middle Aged
	A patient with mixed type Evans syndrome: efficacy of rituximab treatment.
	Park CY, Chung CH. J Korean Med Sci. 2006;21(6):1115-6.
	She was diagnosed as having the mixed type Evans syndrome with the clinical features of symptomatic anemia, jaundice and thrombocytopenia.
16679706	MALE	Middle Aged
	Autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia and gastric cancer appeared in a patient with myasthenia gravis.
	Wakata N, Kiyozuka T, Konno S, Nakazora H, Nomoto N, Sugimoto H, Nemoto H. Intern Med. 2006;45(7):479-81.
	He was diagnosed as Evans' syndrome (AIHA and AITP) with MG. High-doses of immunoglobulin administration improved the anemia, but thrombocytopenia continued.
10734662	MALE	Child
	Immune thrombocytopenia and hemolytic anemia as a presenting manifestation of Hodgkin disease.
	Ertem M, Uysal Z, Yavuz G, Gozdasoglu S. Pediatr Hematol Oncol. 2000;17(2):181-5.
	After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.