Evans syndrome

A rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology.

Coombs-positive hemolytic anemia

A type of hemolytic anemia in which the Coombs test is positive.

Total: 4

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PMID (PMCID)
24299473 (3879039)	OTHER
	Evans syndrome associated with sterile inflammation of the central nervous system: a case report.
	Simon OJ, Kuhlmann T, Bittner S, Muller-Tidow C, Weigt J, Wiendl H, Meuth SG. J Med Case Rep. 2013;7:262.
	Evans syndrome is a rare hematological disease commonly defined as Coombs-positive hemolytic anemia and immune thrombocytopenia.
21088621	MALE	Infant
	Massive hemoperitoneum with splenic infarction in Evans syndrome.
	Ryu EM, Im SA, Chun HJ, Chung NG, Lee JW. J Pediatr Hematol Oncol. 2011;33(1):71-3.
	Evans syndrome is a very rare hematologic autoimmune disease, characterized by a direct Coombs' positive hemolytic anemia and immune thrombocytopenic purpura without a known underlying etiology.
15593044	FEMALE	Adult
	Acute renal failure in a young woman with Fisher-Evans' syndrome.
	De Sanctis LB, Mandreoli M, Poggi C, Pileri S, Casanova S, Santoro A. J Nephrol. 2004;17(5):739-43.
	Fisher-Evans' syndrome, defined as Coombs' positive hemolytic anemia and immune thrombocytopenia, is more frequently associated with the other autoimmune diseases, but not with renal involvement.
11149736	MALE	Adult
	An immunological syndrome featuring transverse myelitis, Evans syndrome and pulmonary infiltrates after unrelated bone marrow transplant in a patient with severe aplastic anemia.
	Richard S, Fruchtman S, Scigliano E, Skerrett D, Najfeld V, Isola L. Bone Marrow Transplant. 2000;26(11):1225-8.
	This featured transverse myelitis, immune mediated Coombs positive hemolytic anemia and immune thrombocytopenia (Evans syndrome), pulmonary infiltrates, eosinophilia, muscle pains and cramps and lichenoid dermatitis all of which may represent manifestations of graft-versus-host disease as they showed response to immunosuppression.