Immune-mediated necrotizing myopathy

Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.

Myopathy

A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.


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PMID (PMCID)
30788073
 OTHER
Anti-HMG-CoA reductase myopathy, an undesirable evolution of statin induced myopathy: a case report.
Upreti S, Fayyaz B, Bongu RP.
J Community Hosp Intern Med Perspect. 2019;9(1):33-35.
However, an entity called Immune Mediated Necrotizing Myopathy (IMNM), a type of autoimmune mediated myopathy, has been recognized and characterized in patients with history of statin exposure where there is persistence of proximal muscle weakness, CK elevation and myofiber necrosis can be seen on muscle biopsy even after stopping statins.
27922497
 MIXED_SAMPLE Middle Aged
Autoimmune Myopathies.
Mammen AL.
Continuum (Minneap Minn). 2016;22(6, Muscle and Neuromuscular Junction Disorders):1852-1870.
The most common subtypes of autoimmune myopathies are dermatomyositis, immune-mediated necrotizing myopathy, antisynthetase syndrome, and overlap syndromes; isolated polymyositis is an exceptionally rare disease.
22436377
 FEMALE
A pediatric patient with myopathy associated with antibodies to a signal recognition particle.
Kawabata T, Komaki H, Saito T, Saito Y, Nakagawa E, Sugai K, Sasaki M, Hayashi YK, Nishino I, Momomura M, Kizawa T, Imagawa T, Yokota S.
Brain Dev. 2012;34(10):877-80.
We report the case of a 15-year-old Japanese girl with myopathy associated with antibodies to a signal recognition particle (anti-SRP myopathy).
12235311
 MIXED_SAMPLE Adult
Myopathy with antibodies to the signal recognition particle: clinical and pathological features.
Miller T, Al-Lozi MT, Lopate G, Pestronk A.
J Neurol Neurosurg Psychiatry. 2002;73(4):420-8.
The anti-SRP myopathy was compared with myopathology in other types of inflammatory and immune myopathies.