Immune-mediated necrotizing myopathy

Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.

Myositis

A general term for inflammation of the muscles without respect to the underlying cause.


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PMID (PMCID)
29794576
 FEMALE Adult
Case of Anti-Single Recognition Particle-Mediated Necrotizing Myopathy After Influenza Vaccination.
Mamarabadi M, Baisre A, Leitch M, Hsu V, Kanduri JS, Chen S.
J Clin Neuromuscul Dis. 2018;19(4):211-216.
Immune-mediated necrotizing myopathy may be associated with myositis-specific autoantibodies including anti-single recognition particle and anti-3-hydroxy-3- methylglutaryl-coenzyme A reductase, infectious agents (HIV or hepatitis C), other connective tissue disorders (such as scleroderma), and malignancy.
27573534
 MALE Middle Aged
Immune Mediated Necrotizing Myopathy: a Cause of Isolated Myopathy of Neck Extensor Muscle.
Sehgal R, Medina-Flores R, Yachoui R, Kenney CV.
Clin Med Res. 2016;14(3-4):145-150.
Immune mediated necrotizing myopathy (IMNM) is a unique form of myositis that is characterized by distinct muscle biopsy features including abundant myofiber necrosis, degeneration, and regeneration with only minimal, if any, inflammation on muscle biopsy.