Carcinosarcoma of the corpus uteri

Carcinosarcoma of the corpus uteri is a rare, malignant, mixed epithelial and mesenchymal tumor of the uterine body composed of high-grade carcinomatous and sarcomatous elements. It may present with vaginal bleeding, abnormal vaginal discharge, abdominal pain and/or pelvic mass, with a polypoid tumor sometimes protruding through the cervical canal. Association with Tamoxifen therapy, long-term unopposed estrogen use and previous pelvic radiotherapy has been reported.

Endometrial carcinoma

A carcinoma of the endometrium, the mucous lining of the uterus.


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PMID (PMCID)
7194144
 FEMALE Middle Aged
Histogenesis and culture of human uterine carcinosarcoma.
Ishiwata I, Ishiwata C, Nagayama T, Ishikawa H.
Cancer Res. 1981;41(5):1978-83.
We set out to ascertain whether uterine carcinosarcoma represents: (a) a "collision tumor," i.e., a mixture of two histogenetically distinct malignant cell populations (endometrial carcinoma and sarcoma); (b) a "combination tumor" with both histological elements of common stem cell origin; or (c) a "composition tumor," i.e., an endometrial carcinoma with reactive, atypical stroma.
7194144
 FEMALE Middle Aged
Histogenesis and culture of human uterine carcinosarcoma.
Ishiwata I, Ishiwata C, Nagayama T, Ishikawa H.
Cancer Res. 1981;41(5):1978-83.
We set out to ascertain whether uterine carcinosarcoma represents: (a) a "collision tumor," i.e., a mixture of two histogenetically distinct malignant cell populations (endometrial carcinoma and sarcoma); (b) a "combination tumor" with both histological elements of common stem cell origin; or (c) a "composition tumor," i.e., an endometrial carcinoma with reactive, atypical stroma.