Carcinosarcoma of the corpus uteri

Carcinosarcoma of the corpus uteri is a rare, malignant, mixed epithelial and mesenchymal tumor of the uterine body composed of high-grade carcinomatous and sarcomatous elements. It may present with vaginal bleeding, abnormal vaginal discharge, abdominal pain and/or pelvic mass, with a polypoid tumor sometimes protruding through the cervical canal. Association with Tamoxifen therapy, long-term unopposed estrogen use and previous pelvic radiotherapy has been reported.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).


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PMID (PMCID)
26775366
 FEMALE Middle Aged
Postradiation carcinosarcoma of the corpus uteri--a case report.
Zwierzchowska A, Panek G, Gajewska M.
Eur J Gynaecol Oncol. 2015;36(6):746-9.
A case of carcinosarcoma of the corpus uteri in a woman with a history of pelvic irradiation for cervical carcinoma is reported.
25197413
 FEMALE Middle Aged
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R.
Int J Clin Exp Pathol. 2014;7(8):5295-301.
Uterine carcinosarcoma (malignant mixed Mullerian tumor, MMMT) is a rare aggressive malignant tumor, which demonstrates both malignant epithelial (carcinoma) and mesenchymal (sarcoma) components.
19111933
 FEMALE Middle Aged
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis.
Froio E, D'Adda T, Fellegara G, Martella E, Caruana P, Pruneri G, Pesci A, Rindi G.
Lung Cancer. 2009;64(3):371-7.
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis.
18301238
 FEMALE
Array-based comparative genomic hybridization (aCGH) analysis is a useful tool for distinguishing primary pulmonary from metastatic neuroendocrine carcinoma to the lung.
Mhawech-Fauceglia P, Pejovic T, Dim D, Fang X, Conroy J, Lele S, Cheney R, Odunsi K.
Appl Immunohistochem Mol Morphol. 2008;16(3):291-5.
We report a case of a 71-year-old woman diagnosed with uterine carcinosarcoma associated with high-grade neuroendocrine carcinoma (NEC).
17504386
 FEMALE
Occult metastatic lung carcinoma presenting as locally advanced uterine carcinosarcoma on positron emission tomography/computed tomography imaging.
Parini CL, Mathis D, Leath CA 3rd.
Int J Gynecol Cancer. 2007;17(3):731-4.
Occult metastatic lung carcinoma presenting as locally advanced uterine carcinosarcoma on positron emission tomography/computed tomography imaging.
16028671
 FEMALE Adult
Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study.
Raspollini MR, Taddei GL, Marchionni M, Bacci S, Romagnoli P.
Ultrastruct Pathol. 2005;29(2):149-55.
Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study.
7230832
 FEMALE Middle Aged
Uterine sarcoma following adjuvant radiotherapy for rectal carcinoma.
Marmion PJ, Goldfarb PM, Youngkin TP.
J Surg Oncol. 1981;17(1):63-7.
The present report describes the first reported case of the development of a uterine carcinosarcoma more than 9 years after preoperative radiotherapy to the midpelvis for rectal carcinoma.