Carcinosarcoma of the corpus uteri

Carcinosarcoma of the corpus uteri is a rare, malignant, mixed epithelial and mesenchymal tumor of the uterine body composed of high-grade carcinomatous and sarcomatous elements. It may present with vaginal bleeding, abnormal vaginal discharge, abdominal pain and/or pelvic mass, with a polypoid tumor sometimes protruding through the cervical canal. Association with Tamoxifen therapy, long-term unopposed estrogen use and previous pelvic radiotherapy has been reported.

Sarcoma

A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.


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(per page)
PMID (PMCID)
26793764
(4688829)
 OTHER
Delayed and clinically isolated port site carcinosarcoma recurrence as an early indicator of disseminated disease.
Dandapani M, Seagle BL, Chacho MS, Shahabi S.
Gynecol Oncol Rep. 2015;14:12-5.
A 71-year-old woman with suspected endometrial cancer underwent robotic-assisted hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node dissection, and infracolic omentectomy revealing a stage II uterine carcinosarcoma with components of serous adenocarcinoma and undifferentiated spindle cell sarcoma.
25197413
 FEMALE Middle Aged
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R.
Int J Clin Exp Pathol. 2014;7(8):5295-301.
Uterine carcinosarcoma (malignant mixed Mullerian tumor, MMMT) is a rare aggressive malignant tumor, which demonstrates both malignant epithelial (carcinoma) and mesenchymal (sarcoma) components.
7194144
 FEMALE Middle Aged
Histogenesis and culture of human uterine carcinosarcoma.
Ishiwata I, Ishiwata C, Nagayama T, Ishikawa H.
Cancer Res. 1981;41(5):1978-83.
In in vitro cultures of human uterine carcinosarcoma, we could separate two distinct, different cell types and succeeded in establishing adenocarcinoma cell lines (HWUA-1 and HWUA-2) and sarcoma cell lines (HWUS-1, HWUS-1a, and HWUS-2).
7194144
 FEMALE Middle Aged
Histogenesis and culture of human uterine carcinosarcoma.
Ishiwata I, Ishiwata C, Nagayama T, Ishikawa H.
Cancer Res. 1981;41(5):1978-83.
We set out to ascertain whether uterine carcinosarcoma represents: (a) a "collision tumor," i.e., a mixture of two histogenetically distinct malignant cell populations (endometrial carcinoma and sarcoma); (b) a "combination tumor" with both histological elements of common stem cell origin; or (c) a "composition tumor," i.e., an endometrial carcinoma with reactive, atypical stroma.