Name: PubCaseFinder
License: http://creativecommons.org/licenses/by/2.1/jp/
Keywords: PubCaseFinder,PCF,Rare Disease,Phenotype,Gene,Match,Assist

Dermatomyositis

A type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness.

Melanoma

The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).

Total: 51

(per page)

PMID (PMCID)
30723666	OTHER
	Anti-MDA5 antibody-positive rapidly progressive interstitial pneumonia without cutaneous manifestations.
	Aoyama J, Hayashi H, Yajima C, Takoi H, Tanaka T, Kashiwada T, Kokuho N, Terasaki Y, Nishikawa A, Gono T, Kuwana M, Saito Y, Abe S, Seike M, Gemma A. Respir Med Case Rep. 2019;26:193-196.
	Although typical skin findings suggestive of dermatomyositis were absent, anti-melanoma differentiation-associate gene (anti-MDA5) antibody was positive.
30449789	MIXED_SAMPLE
	Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis.
	Sakamoto N, Ishimoto H, Nakashima S, Yura H, Miyamura T, Okuno D, Hara A, Kitazaki T, Kakugawa T, Ishimatsu Y, Satoh M, Mukae H. Intern Med. 2019;58(6):837-841.
	Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM).
30449789	MIXED_SAMPLE
	Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis.
	Sakamoto N, Ishimoto H, Nakashima S, Yura H, Miyamura T, Okuno D, Hara A, Kitazaki T, Kakugawa T, Ishimatsu Y, Satoh M, Mukae H. Intern Med. 2019;58(6):837-841.
	Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM).
31249780	OTHER
	Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough.
	Deitchman AR, Kalchiem-Dekel O, Todd N, Reed RM. Respir Med Case Rep. 2019;28:100886.
	Clinically amyopathic dermatomyositis (CADM) was confirmed through serum positivity for anti-Melanoma Differentiation Associated Protein-5 (MDA-5) antibody.
30746580	OTHER
	Utilize lung ultrasound B-lines and KL-6 to monitor anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis-associated interstitial lung disease: a case report and literature review.
	Wang Y, Chen S, Lin Z, Lin J, Xie X, Lin Q, Du G, Huang X, Matucci-Cerinic M, Furst DE. Clin Rheumatol. 2019;38(5):1433-1436.
	Herein, we report a case with anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis-associated ILD, successfully treated with high-dose methylprednisolone, cyclophosphamide, intravenous immunoglobulin, pirfenidone, and followed using lung ultrasound and KL-6.
29867431 (5981633)	OTHER
	Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom.
	Hattori Y, Matsuyama K, Takahashi T, Shu E, Kanoh H, Seishima M. Case Rep Dermatol. 2018;10(2):110-114.
	Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM.
29867431 (5981633)	OTHER
	Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom.
	Hattori Y, Matsuyama K, Takahashi T, Shu E, Kanoh H, Seishima M. Case Rep Dermatol. 2018;10(2):110-114.
	Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM.
29984753	FEMALE	Middle Aged
	Anti-MDA5 Antibody-positive Dermatomyositis Complicated by Autoimmune-associated Hemophagocytic Syndrome That Was Successfully Treated with Immunosuppressive Therapy and Plasmapheresis.
	Fujita Y, Fukui S, Suzuki T, Ishida M, Endo Y, Tsuji S, Takatani A, Igawa T, Shimizu T, Umeda M, Sumiyoshi R, Nishino A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Abe K, Kawakami A. Intern Med. 2018;57(23):3473-3478.
	A 56-year-old Japanese woman with muscle weakness, increased creatine kinase and aldolase levels, and characteristic cutaneous lesions was diagnosed with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis.
30158335	FEMALE	Middle Aged
	Anti-MDA5 antibody-positive hypomyopathic dermatomyositis complicated with pneumomediastinum.
	Yashiro M, Asano T, Sato S, Kobayashi H, Watanabe H, Miyata M, Migita K. Fukushima J Med Sci. 2018;64(2):89-94.
	Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis (CADM) is frequently associated with rapidly progressive interstitial lung disease (RP-ILD) resulting in high mortality.
28040421	FEMALE	Adult
	Anti-MDA5 dermatomyositis mimicking psoriatic arthritis.
	Cabezas-Rodriguez I, Morante-Bolado I, Brandy-Garcia A, Queiro-Silva R, Mozo L, Ballina-Garcia FJ. Reumatol Clin. 2018;14(4):224-226.
	Herein, we describe the case of a patient with dermatomyositis, initially diagnosed as psoriatic arthritis, in which the performance of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was decisive to establish a definitive diagnosis.
29338781 (5770999)	MALE	Middle Aged
	Correlation between disease activity and serum ferritin in clinically amyopathic dermatomyositis with rapidly-progressive interstitial lung disease: a case report.
	Yamada K, Asai K, Okamoto A, Watanabe T, Kanazawa H, Ohata M, Ohsawa M, Hirata K. BMC Res Notes. 2018;11(1):34.
	Clinically amyopathic dermatomyositis with anti-Melanoma Differentiation-Associated gene 5 (MDA5) antibody often presents with severe interstitial lung disease.
30632536	OTHER
	Histological Findings of Organizing Pneumonia, Based on Transbronchial Lung Biopsy, May Predict Poor Outcome in Polymyositis and Dermatomyositis: Report of Two Autopsied Cases.
	Oiwa H, Kondo T, Funaki M, Morito T, Yasui H, Kamiya T. Arch Rheumatol. 2018;33(3):376-380.
	One is a 66-year-old female patient with clinically amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody, and another is a 61-year-old female patient with polymyositis with anti-Jo-1 antibody.
29269659 (5919868)	FEMALE	Middle Aged
	Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy.
	Koga T, Kaieda S, Okamoto M, Masuda K, Fujimoto K, Sakamoto S, Nakamura M, Tominaga M, Kawayama T, Fujimoto K, Hoshino T, Ida H. Intern Med. 2018;57(7):1039-1043.
	She tested positive for the presence of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, although she had no skin manifestations of dermatomyositis.
28824190	FEMALE
	A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody.
	Yamazaki K, Wakabayashi H, Suganami Y, Sano S, Wakunami Y, Katayama T, Deguchi K, Nagotani S, Kishida M. Acta Med Okayama. 2017;71(4):341-344.
	A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody.
25698373	FEMALE
	A case of anti-MDA5-positive rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis ameliorated by rituximab, in addition to standard immunosuppressive treatment.
	Koichi Y, Aya Y, Megumi U, Shunichi K, Masafumi S, Hiroaki M, Masahiko K, Shinsuke K, Manabu U, Kenichiro H, Fumiaki A, Nozomi A, Toshitaka M, Masayoshi Y, Chikako K, Yoshinao M, Tatsuo S, Masahiko K. Mod Rheumatol. 2017;27(3):536-540.
	Rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) associated with antibodies to melanoma differentiation-associated gene5 (MDA5) results in a high mortality rate.
28413686 (5387408)	OTHER
	Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases treated with mycophenolate.
	Hayashi M, Aoki A, Asakawa K, Sakagami T, Kikuchi T, Takada T. Respirol Case Rep. 2017;5(4):e00235.
	A 59-year-old Japanese man diagnosed with interstitial lung disease associated with amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA-5) antibodies was treated with intravenous methyl prednisolone (PSL) 10008201mg, oral PSL 18201mg/kg, and oral cyclosporin 2008201mg daily.
29225988 (5684540)	OTHER
	Effective Administration of Rituximab in Anti-MDA5 Antibody-Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review.
	Ogawa Y, Kishida D, Shimojima Y, Hayashi K, Sekijima Y. Case Rep Rheumatol. 2017;2017:5386797.
	We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab).
28346662	MIXED_SAMPLE	Middle Aged
	Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules.
	Koguchi-Yoshioka H, Okiyama N, Iwamoto K, Matsumura Y, Ogawa T, Inoue S, Watanabe R, Fujimoto M. Br J Dermatol. 2017;177(5):1442-1446.
	Intravenous immunoglobulin contributes to control anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis with palmar violaceous macules/papules.
28346662	MIXED_SAMPLE	Middle Aged
	Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules.
	Koguchi-Yoshioka H, Okiyama N, Iwamoto K, Matsumura Y, Ogawa T, Inoue S, Watanabe R, Fujimoto M. Br J Dermatol. 2017;177(5):1442-1446.
	Autoantibodies to melanoma differentiation-associated protein 5 (MDA5) are associated with a subset of dermatomyositis (DM) patients who have rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis.
28361863	MALE	Middle Aged
	Trichilemmal cystis in metastatic melanoma: a case report.
	Savarese I, Grazzini M, Gori A, D'Errico A, Doni L, Scarfi F, Covarelli P, Di Costanzo F, De Giorgi V. Exp Oncol. 2017;39(1):86-87.
	The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus.