Marchiafava-Bignami disease


Seizure

Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.


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PMID (PMCID)
22306402
 MALE Middle Aged
Alcoholic ketoacidosis coincides with acute Marchiafava-Bignami disease.
Chen MH, Cheng CA.
Am J Emerg Med. 2012;30(9):2087.e7-8.
Marchiafava-Bignami disease, a rare alcohol-related disorder, characterized by altered mental status, seizure, and multifocal central nervous system signs, which results from progressive demyelination and necrosis of corpus callosum.
9551462
 MALE
[Subacute encephalopathy with epileptic seizures in a patient with chronic alcoholism (SESA syndrome)].
Boroojerdi B, Hungs M, Biniek R, Noth J.
Nervenarzt. 1998;69(2):162-5.
It is quite distinct from alcohol withdrawal syndromes, such as delirium, withdrawal seizures or CNS complications of alcohol, such as Wernicke-Korsakow syndrome, central pontine myelinolysis or Marchiafava-Bignami disease, and was proposed in 1981 by Niedermeyer and coworkers.