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Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Hypertension

The presence of chronic increased pressure in the systemic arterial system.

Total: 40

(per page)

PMID (PMCID)
31149361	OTHER
	Successful Use of Pulmonary Vasodilators in Acute Chest Syndrome Complicated by Persistent Right Ventricular Failure.
	DesJardin JT, Zier LS. Case Rep Cardiol. 2019;2019:4681392.
	Pulmonary hypertension (PH) is a known consequence of sickle cell disease (SCD) and is associated with increased mortality and more frequent episodes of acute chest syndrome (ACS).
30033820 (6083805)	OTHER
	Riociguat use in sickle cell related chronic thromboembolic pulmonary hypertension: A case series.
	Weir NA, Conrey A, Lewis D, Mehari A. Pulm Circ. 2018;8(4):2045894018791802.
	Classified as WHO Group 5, there are no therapies approved for the treatment of sickle cell disease-pulmonary hypertension.
30033820 (6083805)	OTHER
	Riociguat use in sickle cell related chronic thromboembolic pulmonary hypertension: A case series.
	Weir NA, Conrey A, Lewis D, Mehari A. Pulm Circ. 2018;8(4):2045894018791802.
	Thromboembolic disease is prevalent in sickle cell disease and can lead to pulmonary hypertension.
29319041 (5760875)	OTHER
	Successful pulmonary thromboendarterectomy in a patient with sickle cell disease and associated resolution of a leg ulcer.
	Agrawal A, Shah R, Bacchetta MD, Talwar A. Lung India. 2018;35(1):73-77.
	Pulmonary hypertension (PH) is a relatively frequent and severe complication of sickle cell disease (SCD).
28333416	MIXED_SAMPLE	Child
	Severe transplant-associated thrombotic microangiopathy in patients with hemoglobinopathies.
	Abusin GA, Abu-Arja R, Bajwa RPS, Horwitz EM, Auletta JJ, Rangarajan HG. Pediatr Blood Cancer. 2017;64(9):.
	A 2.5-year-old male with sickle cell disease developed TA-TMA-associated pericardial tamponade, severe hypertension, and acute kidney injury 2 months after transplant.
29222289	MALE	Adult
	What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?
	Willen SM, Gladwin MT. Hematology Am Soc Hematol Educ Program. 2017;2017(1):431-434.
	What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?
27692921	MALE	Middle Aged
	[Patient with homozygous sickle cell disease and free flap surgery: Ensuring the success of the procedure].
	Deneuve S, Maire L, Bachelot V, Dammacco MA, Zrounba P, Delay E. Ann Chir Plast Esthet. 2017;62(2):171-175.
	The preoperative examination has to assess usual sickle cell disease comorbidities such as kidney failure, heart failure or pulmonary hypertension.
26424303	FEMALE	Adult
	A Sickle Cell Disease Patient with Severe Tricuspid Regurgitation and Early Developed Pulmonary Hypertension.
	Vaidya G, Sarwar M, Sun Z, Wei T, Liu K. Intern Med. 2015;54(19):2459-62.
	A Sickle Cell Disease Patient with Severe Tricuspid Regurgitation and Early Developed Pulmonary Hypertension.
26734142 (4693704)	OTHER
	Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.
	Kord Valeshabad A, Wanek J, Molokie RE, Machado RF, Gordeuk VR, Shahidi M. Clin Case Rep. 2015;3(12):1038-41.
	Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.
26734142 (4693704)	OTHER
	Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.
	Kord Valeshabad A, Wanek J, Molokie RE, Machado RF, Gordeuk VR, Shahidi M. Clin Case Rep. 2015;3(12):1038-41.
	Assessment of the conjunctival microcirculation using noninvasive imaging may improve understanding of microvascular hemodynamic alterations that occur due to pulmonary hypertension in sickle cell disease.
21657139	MALE	Adult
	Homozygous sickle cell anemia and secondary complications: a case study.
	Yontz CJ, Waller KV. Clin Lab Sci. 2011;24(2):78-84.
	A 26-year-old African-American male presented with chest and back pain, fatigue and a history of the following: homozygous sickle cell anemia, pain crises, stroke, hip replacement following avascular necrosis of the femoral head, priapism, chronic transfusions, iron overload, hypertension, migraine headaches, port infections, depression and type II diabetes.
20409257	MALE	Adult
	Sickle-cell anemia and pulmonary hypertension.
	Ninkovich GM, Miller SK, Alpert PT. J Am Acad Nurse Pract. 2010;22(4):198-204.
	To provide nurse practitioners (NPs) information about sickle-cell disease (SCD) and pulmonary hypertension (PHTN) as a complication.
20409257	MALE	Adult
	Sickle-cell anemia and pulmonary hypertension.
	Ninkovich GM, Miller SK, Alpert PT. J Am Acad Nurse Pract. 2010;22(4):198-204.
	Sickle-cell anemia and pulmonary hypertension.
19302944 (2903963)	FEMALE	Child
	Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia.
	Frye RE. Pediatr Neurol. 2009;40(4):298-301.
	A 10-year-old African American girl with sickle-cell anemia developed headaches and seizures associated with hypertension during hospitalization for a pulmonary abscess.
19066384 (2756016)	FEMALE	Adult
	Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.
	Kato GJ, Gladwin MT. JAMA. 2008;300(22):2638-46.
	A 34-year-old African American woman with sickle cell disease and history of relatively severe hemolysis, chronic leg ulcers, and mild pulmonary hypertension presented with a new ischemic stroke.
18363174	FEMALE	Infant
	Pulmonary hypertension in children with Evans syndrome.
	Connor P, Veys P, Amrolia P, Haworth S, Ashworth M, Moledina S. Pediatr Hematol Oncol. 2008;25(2):93-8.
	The authors speculate that the pulmonary hypertension was caused by the underlying immune dysregulation and hemolysis and that Evans syndrome joins the list of other hemolytic anemias that cause pulmonary hypertension, such as sickle cell disease, thalassemia, and paroxysmal nocturnal hemoglobinuria.
18363174	FEMALE	Infant
	Pulmonary hypertension in children with Evans syndrome.
	Connor P, Veys P, Amrolia P, Haworth S, Ashworth M, Moledina S. Pediatr Hematol Oncol. 2008;25(2):93-8.
	The authors speculate that the pulmonary hypertension was caused by the underlying immune dysregulation and hemolysis and that Evans syndrome joins the list of other hemolytic anemias that cause pulmonary hypertension, such as sickle cell disease, thalassemia, and paroxysmal nocturnal hemoglobinuria.
18212317	MALE
	Pulmonary hypertension: an increasingly recognized complication of hereditary hemolytic anemias and HIV infection.
	Barnett CF, Hsue PY, Machado RF. JAMA. 2008;299(3):324-31.
	Considering the prevalence of pulmonary vascular disease in these populations, sickle cell disease and HIV disease may be the most common causes of pulmonary hypertension worldwide.
18492535	MALE	Child
	Symptomatic pulmonary hypertension in a child with sickle cell disease.
	Villavicencio K, Ivy D, Cole L, Nuss R. J Pediatr. 2008;152(6):879-81.
	Pulmonary hypertension is a survival-limiting complication in adults with homozygous sickle cell disease (SS), but little is known about the development, course, or best treatment of pulmonary hypertension in children with SS.
18492535	MALE	Child
	Symptomatic pulmonary hypertension in a child with sickle cell disease.
	Villavicencio K, Ivy D, Cole L, Nuss R. J Pediatr. 2008;152(6):879-81.
	Pulmonary hypertension is a survival-limiting complication in adults with homozygous sickle cell disease (SS), but little is known about the development, course, or best treatment of pulmonary hypertension in children with SS.