Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Cholestasis

Impairment of bile flow due to obstruction in bile ducts.


Total: 2

                       


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PMID (PMCID)
18603711
 MALE Adult
Sickle cell hepatopathy.
Bandyopadhyay R, Bandyopadhyay SK, Dutta A.
Indian J Pathol Microbiol. 2008;51(2):284-5.
We describe a 26-year-male with homozygous sickle cell disease who had this unique hepatic presentation and was documented to have characteristic findings of cholestasis, portal inflammation and sinusoidal dilatation on histopathology.
17171533
 MALE Middle Aged
Exacerbation of sickle cell disease itself as a cause of abnormal liver chemistry tests.
Stanca CM, Fiel MI, Schiano TD.
Dig Dis Sci. 2007;52(1):176-8.
Liver pathology occurring in patients with sickle cell disease is commonly related to viral hepatitis or hepatic iron deposition due to repeated transfusions; cholestasis and cirrhosis may also occur.