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Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Intrahepatic cholestasis

Impairment of bile flow due to obstruction in the small bile ducts within the liver.

Total: 18

(per page)

PMID (PMCID)
28696845	MIXED_SAMPLE	Adult
	Decompensated Cirrhosis and Sickle Cell Disease: Case Reports and Review of the Literature.
	D'Ambrosio R, Maggioni M, Donato MF, Lampertico P, Cappellini MD, Graziadei G. Hemoglobin. 2017;41(2):131-133.
	Few data have been provided on chronic sickle cell intrahepatic cholestasis (SCIC) clinical course, although cirrhosis has been reported in sickle cell disease.
25484513	OTHER
	Reversal of liver function without exchange transfusion in sickle cell intrahepatic cholestasis.
	Hosiriluck N, Rassameehiran S, Argueta E, Tijani L. Proc (Bayl Univ Med Cent). 2014;27(4):361-3.
	Sickle cell intrahepatic cholestasis (SCIC) is a rare but fatal complication of sickle cell disease.
23888237 (3719104)	OTHER
	Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature.
	Blinder MA, Geng B, Lisker-Melman M, Crippin JS, Korenblat K, Chapman W, Shenoy S, Field JJ. Hematol Rep. 2013;5(1):1-4.
	Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload.
21490769 (3065851)	OTHER
	Intrahepatic cholestasis in sickle cell disease: a case report.
	Brunetta DM, Silva-Pinto AC, do Carmo Favarin de Macedo M, Bassi SC, Piccolo Feliciano JV, Ribeiro FB, Prado Bde P Jr, De Santis GC, de Lucena Angulo I, Covas DT. Anemia. 2011;2011:975731.
	Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients with homozygous sickle cell anemia.
21490769 (3065851)	OTHER
	Intrahepatic cholestasis in sickle cell disease: a case report.
	Brunetta DM, Silva-Pinto AC, do Carmo Favarin de Macedo M, Bassi SC, Piccolo Feliciano JV, Ribeiro FB, Prado Bde P Jr, De Santis GC, de Lucena Angulo I, Covas DT. Anemia. 2011;2011:975731.
	Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients with homozygous sickle cell anemia.
16895293	MALE	Middle Aged
	Case of fatal sickle cell intrahepatic cholestasis despite use of exchange transfusion in an African-American patient.
	Costa DB, Miksad RA, Buff MS, Wang Y, Dezube BJ. J Natl Med Assoc. 2006;98(7):1183-7.
	Sickle cell intrahepatic cholestasis (SCIC) is a rare complication of sickle cell anemia, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course.
16371935	FEMALE	Adult
	Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis.
	Baichi MM, Arifuddin RM, Mantry PS, Bozorgzadeh A, Ryan C. Transplantation. 2005;80(11):1630-2.
	We report a rare case of liver transplantation for acute sickle cell intrahepatic cholestasis and a novel case of transplantation in a patient with sickle cell disease and sclerosing cholangitis.
14655071	FEMALE	Adult
	Sickle cell anemia connected with chronic intrahepatic cholestasis: a case report.
	Altintas E, Tiftik EN, Ucbilek E, Sezgin O. Turk J Gastroenterol. 2003;14(3):215-8.
	Sickle cell anemia connected with chronic intrahepatic cholestasis: a case report.
14655071	FEMALE	Adult
	Sickle cell anemia connected with chronic intrahepatic cholestasis: a case report.
	Altintas E, Tiftik EN, Ucbilek E, Sezgin O. Turk J Gastroenterol. 2003;14(3):215-8.
	The findings in this case suggest that therapeutic erythrocyte apheresis may benefit patients who have unusual complications of sickle cell disease, such as chronic intrahepatic cholestasis in the liver.
14655071	FEMALE	Adult
	Sickle cell anemia connected with chronic intrahepatic cholestasis: a case report.
	Altintas E, Tiftik EN, Ucbilek E, Sezgin O. Turk J Gastroenterol. 2003;14(3):215-8.
	Chronic intrahepatic cholestasis is an uncommon complication in patients with sickle cell disease.
11889439	MALE	Middle Aged
	Combined liver and kidney transplantation in a patient with sickle cell disease.
	Ross AS, Graeme-Cook F, Cosimi AB, Chung RT. Transplantation. 2002;73(4):605-8.
	We describe the case of a patient with sickle cell anemia who underwent successful combined liver and kidney transplantation after the development of acute sickle cell intrahepatic cholestasis and renal failure requiring continuous venovenous hemodialysis.
11889439	MALE	Middle Aged
	Combined liver and kidney transplantation in a patient with sickle cell disease.
	Ross AS, Graeme-Cook F, Cosimi AB, Chung RT. Transplantation. 2002;73(4):605-8.
	Sickle cell intrahepatic cholestasis is a potentially fatal end-organ complication of sickle cell anemia.
12364877	MALE	Adult
	Liver transplantation in a patient with S(beta)o-thalassemia.
	Gilli SC, Boin IF, Sergio Leonardi L, Luzo AC, Costa FF, Saad ST. Transplantation. 2002;74(6):896-8.
	In this report, we describe the transfusional program of a patient presenting sickle cell disease and intrahepatic cholestasis who underwent liver transplantation 2 years ago.
12394969	MALE	Adult
	Sickle cell disease, extreme hyperbilirubinemia, and pericardial tamponade: case report and review of the literature.
	Khurshid I, Anderson L, Downie GH, Pape GS. Crit Care Med. 2002;30(10):2363-7.
	We report a patient who presented with intrahepatic cholestasis, a rare and potentially lethal complication of sickle cell disease.
12394969	MALE	Adult
	Sickle cell disease, extreme hyperbilirubinemia, and pericardial tamponade: case report and review of the literature.
	Khurshid I, Anderson L, Downie GH, Pape GS. Crit Care Med. 2002;30(10):2363-7.
	Sickle cell intrahepatic cholestasis, a potentially fatal complication of sickle cell disease, can present with abdominal pain, acute hepatomegaly, coagulopathy, hyperbilirubinemia, and fulminant hepatic failure.
10708131	MALE	Child
	Liver transplantation in a patient with acute liver failure due to sickle cell intrahepatic cholestasis.
	Emre S, Kitibayashi K, Schwartz ME, Ahn J, Birnbaum A, Thung SN, Miller CM. Transplantation. 2000;69(4):675-6.
	Sickle cell intrahepatic cholestasis is a potentially catastrophic complication of sickle cell anemia Once acute liver failure develops, transplantation is the only option.
7485022	MALE	Adult
	Sickle cell intrahepatic cholestasis: approach to a difficult problem.
	Shao SH, Orringer EP. Am J Gastroenterol. 1995;90(11):2048-50.
	Sickle cell intrahepatic cholestasis is a rare but potentially fatal complication of sickle cell disease.
6698374	FEMALE	Adult
	Hepatic biloma complicating sickle cell disease. A case report and a review of the literature.
	Middleton JP, Wolper JC. Gastroenterology. 1984;86(4):743-4.
	Previously reported hepatobiliary complications of sickle cell disease include cholelithiasis, intrahepatic cholestasis, cirrhosis, hepatic crisis, abscess, and infarction.