Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Asplenia

Absence (aplasia) of the spleen.


Total: 8

                       


(per page)
PMID (PMCID)
21803935
 MALE Young Adult
Severe unilateral headache caused by skull bone infarction with epidural haematoma in a patient with sickle cell disease.
Arends S, Coebergh JA, Kerkhoffs JL, van Gils A, Koppen H.
Cephalalgia. 2011;31(12):1325-8.
The clinical manifestations of sickle cell disease (SCD) vary, but may be attributed to vaso-occlusion, chronic hemolytic anemia, and infections as a result of functional asplenia.
18574127
 MALE Adult
Focal Salmonella enteritidis infection in a patient with HIV infection and other multiple causes of immunodeficiency.
Peppa D, Sutton JK, Bin-Reza F, Morris-Jones SD, Miller RF.
Int J STD AIDS. 2008;19(7):491-2.
An HIV-infected man receiving antiretroviral therapy-who also had lupus-like vasculitis and membranous glomerulonephritis (treated with prednisolone and azathioprine), beta-thalassaemia minor trait and post-radiotherapy functional asplenia (mimicking sickle cell disease-induced hyposplenism)-developed focal soft issue and bone infection caused by Salmonella enteritidis at the site of previous mycobacterial infection.
15545849
 MALE Adult
Intrathoracic masses due to extramedullary hematopoiesis.
Castelli R, Graziadei G, Karimi M, Cappellini MD.
Am J Med Sci. 2004;328(5):299-303.
We describe massive intrathoracic extramedullary hematopoiesis in a 41-year-old man with compound heterozygosis for beta-thalassemia and sickle cell anemia and functional asplenia.
15776654
 MALE Adult
[Acute chest syndrom in a patient with homozygous sickle cell anemia].
Ndiaye M, Hane AA, Ndir M, Ba O, Cissokho S, Diop-Dia D, Kandji M, Ndiaye S, Toure NO, Diatta A, Niang A, Dia Y.
Dakar Med. 2003;48(1):61-3.
The appearance of pneumopathy in patients suffering from sickle cell anemia is explained by the functional asplenia and the inability of phagocyte cells to destruct bacteria.
12695938
 MALE Adult
[Functional asplenia after severe varicella zoster-infection diagnosis by colour Doppler ultrasound].
Diedrich J, Gorg C, Eissele R, Arnold R.
Z Gastroenterol. 2003;41(4):325-8.
This phenomenon is called functional asplenia and occurs as a complication especially in sickle cell disease, lupus erythematosus and after bone marrow transplantation.
2805534
 FEMALE Adult
Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta (0) thalassemia.
Heck LL, Brittin GM.
Clin Nucl Med. 1989;14(8):557-63.
Her spleen was enlarged threefold and accumulated both radiocolloid and bone-seeking agent on two occasions, demonstrating an exception to the rule in sickle cell anemia that spleens that take up bone-seeking agents demonstrate functional asplenia.
6786810
 MIXED_SAMPLE Adult
Splenic concentration of bone imaging agents in functional asplenia.
Dhekne RD.
Clin Nucl Med. 1981;6(7):313-7.
Three cases of sickle cell disease associated with functional asplenia are described.
904010
 FEMALE
Pleural effusion in sickle cell disease.
Oestreich AE.
J Natl Med Assoc. 1977;69(8):579-80.
Several of these have an increased likelihood of occurrence in sickle cell disease as a direct consequence of sicklemia or of the functional asplenia which develops.