Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Dehydration



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PMID (PMCID)
21461009
 MIXED_SAMPLE Child
[Co-inheritance of autosomal dominant polycystic kidney disease and sickle cell trait in African Americans].
Peces R, Peces C, Cuesta-Lopez E, Vega-Cabrera C, Azorin S, Perez-Duenas V, Selgas R.
Nefrologia. 2011;31(2):162-8.
Metabolic or environmental changes such as hypoxia, acidosis, dehydration, hyperosmolality or hyperthermia may transform silent sickle-cell trait into a syndrome resembling sickle-cell disease with vaso-occlusive crisis due to an accumulation of low deformable red blood cells in the microcirculation originating haematuria from papilar necrosis.
9881989
 MIXED_SAMPLE Adult
Acute nonoliguric renal failure in children associated with nonsteroidal antiinflammatory agents.
Schaller S, Kaplan BS.
Pediatr Emerg Care. 1998;14(6):416-8.
None of the patients had features of hemolytic uremic syndrome, systemic lupus, dehydration, obstructive uropathy or sickle cell disease.
7074213
 MALE Adult
Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration.
Platt OS.
Blood. 1982;59(5):1055-60.
Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration.