Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Unexplained fevers

Episodes of fever for which no infectious cause can be identified.


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PMID (PMCID)
9218905
 MALE Adult
Cytologic diagnosis of fat emboli in peripheral blood during sickle cell infarctive crisis.
van Hoeven KH, Wanner JL, Ballas SK.
Diagn Cytopathol. 1997;17(1):54-6.
We described a 25-yr-old man with sickle cell anemia who developed an infarctive crisis complicated by unexplained fever, neurologic change, and respiratory abnormalities.
6691757
 FEMALE Adult
Fat embolism in sickle cell disease. Report of a case with brief review of the literature.
Shapiro MP, Hayes JA.
Arch Intern Med. 1984;144(1):181-2.
It should be suspected in any patient with sickle cell disease in whom unexplained fever, respiratory, and neurologic symptoms typical of fat emboli develop following the onset of bone pain.