Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Osteomyelitis

Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.


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(per page)
PMID (PMCID)
29528178
 FEMALE Child
Iliopsoas hematoma in a patient with sickle cell disease.
Zielonka B, Cohen AR, Smith-Whitley K, Doshi BS.
Pediatr Blood Cancer. 2018;65(7):e27040.
Although musculoskeletal pain in patients with sickle cell disease (SCD) is most frequently the result of vaso-occlusive episodes, clinicians often consider other etiologies including osteomyelitis, avascular necrosis, and trauma.
29478416
 MALE Infant, Newborn
Salmonella osteomyelitis in a previously healthy neonate: a case report and review of the literature.
Zhan C, Du J, Chen L.
Ital J Pediatr. 2018;44(1):28.
The most frequently isolated bacterium in neonates with osteomyelitis is Staphylococcus aureus, while Salmonella is an unusual organism causing osteomyelitis and is exceedingly rare in non-sickle cell disease children.
29478416
 MALE Infant, Newborn
Salmonella osteomyelitis in a previously healthy neonate: a case report and review of the literature.
Zhan C, Du J, Chen L.
Ital J Pediatr. 2018;44(1):28.
The most frequently isolated bacterium in neonates with osteomyelitis is Staphylococcus aureus, while Salmonella is an unusual organism causing osteomyelitis and is exceedingly rare in non-sickle cell disease children.
28050370
 OTHER
An Unusual Case of Septic Arthritis of the Hip.
Ray U, Dutta S, Sutradhar A.
J Clin Diagn Res. 2016;10(11):DD03-DD05.
Salmonella, as the aetiological agent of osteomyelitis and septic arthritis is rare and has been mostly reported in patients with sickle cell disease or thalassaemia.
28018092
 OTHER
Prosthetic hip infection with Edwardsiella tarda in sickle cell beta thalassemia disease: A case report.
Frumberg DB, Epstein SE, Jauregui JJ, Pivec R, Maheshwari AV.
J Clin Orthop Trauma. 2016;7(Suppl 1):130-133.
A 22-year-old male with combined sickle cell disease and beta thalassemia with a prior history of unknown hip surgeries and treatment for distal tibial osteomyelitis in Africa developed a periprosthetic joint infection; intra-operative cultures confirmed the infecting organism to be Edwardsiella tarda which was sensitive to late-generation cephalosporins and vancomycin.
26790559
 MALE
Orbital wall infarction in child with sickle cell disease.
Janssens C, Claeys L, Maes P, Boiy T, Wojciechowski M.
Acta Clin Belg. 2015;70(6):451-2.
Thus, in young persons with sickle cell disease, it is important to consider orbital wall infarction in the differential diagnosis, since the approach is different from osteomyelitis.
26668420
(4642261)
 MALE Adult
Salmonella Osteomyelitis.
McAnearney S, McCall D.
Ulster Med J. 2015;84(3):171-2.
Salmonella as an aetiological agent in osteomyelitis is essentially rare and salmonella osteomyelitis in itself is predominantly seen in patients with haemoglobinopathies such as sickle cell disease or thalassemia.
25674379
(4323402)
 OTHER
Salmonella osteomyelitis of the hand in an infant with sickle cell disease.
Sinkin JC, Wood BC, Sauerhammer TM, Boyajian MJ, Rogers GF, Oh AK.
Plast Reconstr Surg Glob Open. 2015;3(1):e298.
We report on a 15-month-old patient with sickle cell disease who ultimately developed osteomyelitis of 1 hand after an acute vasoocclusive episode caused 4 extremity dactylitis.
24640211
 FEMALE
Sickle cell disease with osteogenesis imperfecta.
Patil PL, Rao BV.
J Assoc Physicians India. 2013;61(6):415-7.
Skeletal involvement is sickle cell disease is usually in the form of avascular necrosis, dactylitis, joint effusions or osteomyelitis however osteoporosis and long bone fractures are not known in sickle cell disease.
24640211
 FEMALE
Sickle cell disease with osteogenesis imperfecta.
Patil PL, Rao BV.
J Assoc Physicians India. 2013;61(6):415-7.
Skeletal involvement is sickle cell disease is usually in the form of avascular necrosis, dactylitis, joint effusions or osteomyelitis however osteoporosis and long bone fractures are not known in sickle cell disease.
22708038
(3375660)
 OTHER
Multiple bone and joint diseases in a nigerian sickle cell anaemia: a case report.
Olaniyi JA, Alagbe AE, Olutoogun TA, Busari OE.
Mediterr J Hematol Infect Dis. 2012;4(1):e2012023.
This case highlights the fact that bone involvement is the commonest clinical manifestation of Sickle Cell Disease (SCD) both in the acute settings such as painful vaso-occlusive crisis (VOC) and as a source of chronic, progressive debility such as avascular necrosis (AVN), chronic osteomyelitis and fixed flexion deformity of joints.Protracted multiple bone involvement i.e.
22778281
 MALE Adult
Bilateral psoas abscesses and vertebral osteomyelitis in a patient with sickle cell disease.
Asnani M, Williams EW, Cawich S, Reid M, Mansingh A, Shah S, Williams-Johnson J.
BMJ Case Rep. 2010;2010:.
Bilateral psoas abscesses and vertebral osteomyelitis in a patient with sickle cell disease.
19550357
 MALE
Primary subacute Salmonella osteomyelitis of the navicular bone in a child with normal immunity.
Cakmak Celik F, Sayli TR, Ocguder DA, Bozkurt M, Okdemir D.
J Pediatr Orthop B. 2009;18(5):225-7.
can be isolated as a cause of primary subacute haematogenous osteomyelitis, if a usually underlying disorder, such as sickle cell anemia is associated.
19660991
 MALE Adult
Salmonella osteomyelitis of multiple ribs and thoracic vertebra with large psoas muscle abscesses.
Zheng X, Wang J, Wu C, Mehbod AA.
Spine J. 2009;9(11):e1-4.
Salmonella vertebral osteomyelitis is a well-known complication of sickle cell disease.
19725348
 MALE
[Anesthetic considerations in sickle cell anemia: a case report].
Fernandez-Mere LA, Sopena-Zubiria LA, Alvarez-Blanco M.
Rev Esp Anestesiol Reanim. 2009;56(6):389-92.
We report the case of a 16-year-old black boy diagnosed with sickle cell anemia and beta-thalassemia who presented with chronic osteomyelitis of the tibia.
19075548
 FEMALE
Bacteroides fragilis bacteremia associated with vertebral osteomyelitis in a sickle cell patient.
Al-Tawfiq JA.
Intern Med. 2008;47(24):2183-5.
Osteomyelitis and septic arthritis are serious complications of sickle cell disease which occur at rates of 18% and 7%, respectively.
19075548
 FEMALE
Bacteroides fragilis bacteremia associated with vertebral osteomyelitis in a sickle cell patient.
Al-Tawfiq JA.
Intern Med. 2008;47(24):2183-5.
Here, we report an 18-year-old girl with sickle cell disease and suspected spontaneous vertebral osteomyelitis due to Bacteroides fragilis.
17634851
 MIXED_SAMPLE Adult
Different findings in Tc-99m MDP bone scintigraphy of patients with sickle cell disease: report of three cases.
Cerci SS, Suslu H, Cerci C, Yildiz M, Ozbek FM, Balci TA, Yesildag A, Canatan D.
Ann Nucl Med. 2007;21(5):311-4.
Bone marrow necrosis, bone infarcts, osteomyelitis, and aseptic necrosis are common complications in patients with sickle cell disease.
17909339
 MALE Infant
Treatment of acute salmonella epiphyseal osteomyelitis using computed tomography-guided drainage in a child without sickle cell disease.
Abdelgawad AA, Rybak LD, Sheth M, Rabinowitz SS, Jayaram N, Sala DA, van Bosse HJ.
J Pediatr Orthop B. 2007;16(6):415-8.
Treatment of acute salmonella epiphyseal osteomyelitis using computed tomography-guided drainage in a child without sickle cell disease.
16363348
 MALE
Atypical presentation of spondylitis in a case with sickle cell disease.
Devrim I, Kara A, Kanra G, Yazici M, Gucer S, Gumruk F, Cengiz AB, Secmeer G.
Turk J Pediatr. 2005;47(4):369-72.
Salmonella should be considered in the list of etiologic agents of osteomyelitis in sickle cell disease.