Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Obstructive sleep apnea

A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow.


Total: 10

                       


(per page)
PMID (PMCID)
28078488
 MALE Child
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RM.
Sleep Breath. 2017;21(3):697-701.
Chart review was conducted on two pediatric patients with sickle cell disease who experienced resolution of obstructive sleep apnea following hydroxyurea administration.
28078488
 MALE Child
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RM.
Sleep Breath. 2017;21(3):697-701.
While hydroxyurea is the mainstay of treatment for many of the comorbidities associated with sickle cell disease, its effect on obstructive sleep apnea has not been fully investigated.
28078488
 MALE Child
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RM.
Sleep Breath. 2017;21(3):697-701.
The purpose of this project is to help characterize the effects of hydroxyurea on obstructive sleep apnea in children with sickle cell disease and determine its therapeutic role in the condition.
28078488
 MALE Child
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RM.
Sleep Breath. 2017;21(3):697-701.
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
28078488
 MALE Child
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea.
Grady AJ, Hankins JS, Haberman B, Schoumacher R, Stocks RM.
Sleep Breath. 2017;21(3):697-701.
As adenotonsillectomy is associated with significant risks in patients with sickle cell disease, it appears reasonable to consider a period of observation for improvement of obstructive sleep apnea following hydroxyurea administration rather than directly proceeding with surgery.
10996992
 FEMALE
Adenotonsillar hypertrophy: a precipitating factor of cerebrovascular accident in a child with sickle cell anemia.
Wali YA, al-Lamki Z, Soliman H, al-Okbi H.
J Trop Pediatr. 2000;46(4):246-8.
We report a child with sickle cell anemia and marked adenotonsillar hypertrophy resulting in obstructive sleep apnea syndrome.
3390338
 FEMALE Child
Exacerbation of sickle cell disease by obstructive sleep apnea.
Sidman JD, Fry TL.
Arch Otolaryngol Head Neck Surg. 1988;114(8):916-7.
Exacerbation of sickle cell disease by obstructive sleep apnea.
3408243
 FEMALE Child
Stroke associated with obstructive sleep apnea in a child with sickle cell anemia.
Robertson PL, Aldrich MS, Hanash SM, Goldstein GW.
Ann Neurol. 1988;23(6):614-6.
Moreover, because stroke in patients with sickle cell anemia, and maximal tonsillar enlargement (the most common cause of obstructive apnea in children) both have peak incidence at the same age (6-7 years), obstructive sleep apnea may be an important factor in the development of stroke in other children with sickle cell anemia.
3408243
 FEMALE Child
Stroke associated with obstructive sleep apnea in a child with sickle cell anemia.
Robertson PL, Aldrich MS, Hanash SM, Goldstein GW.
Ann Neurol. 1988;23(6):614-6.
Moreover, because stroke in patients with sickle cell anemia, and maximal tonsillar enlargement (the most common cause of obstructive apnea in children) both have peak incidence at the same age (6-7 years), obstructive sleep apnea may be an important factor in the development of stroke in other children with sickle cell anemia.
3408243
 FEMALE Child
Stroke associated with obstructive sleep apnea in a child with sickle cell anemia.
Robertson PL, Aldrich MS, Hanash SM, Goldstein GW.
Ann Neurol. 1988;23(6):614-6.
We describe a child with sickle cell anemia and multiple ischemic infarctions who was found to have severe obstructive sleep apnea and hypoxemia, secondary to adenotonsillar enlargement.