Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Disseminated intravascular coagulation

Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.

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PMID (PMCID)
23057758 (3492084)	OTHER
	Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report.
	Khoshnaw NS, Al-Rawi HA, Nore BF. J Med Case Rep. 2012;6:349.
	Non-malignant conditions associated with bone marrow necrosis are sickle cell anemia, infections, drugs (sulfasalazine, interferon 945, all-trans retinoic acid, granulocyte colony-stimulating factor and fludarabine), disseminated intravascular coagulation, antiphospholipid antibody syndrome and acute graft versus host diseases.
432700	MALE	Adult
	Disseminated intravascular coagulation in sickle cell crisis.
	Corvelli AI, Binder RA, Kales A. South Med J. 1979;72(4):505-6.
	We conclude that DIC can occur as a result of sickle cell crisis in the absence of sepsis and we recommend that patients with sickle cell disease, particularly those with hemoglobin SC disease, presenting in crisis should be considered at risk for the development of disseminated intravascular coagulation.