Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Abnormal hemoglobin

Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.


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PMID (PMCID)
30574230
 FEMALE Middle Aged
Vanishing spleen syndrome post right partial nephrectomy in a sicklemic patient.
Khan K, Leroux O, Saeed S, Iqbal F, Ahmed L, Davis-Joseph B.
Pan Afr Med J. 2018;30:211.
The spleen is the most affected organ in sickle cell disease and the mechanism of auto infarction is thought to result from the crystallization of abnormal hemoglobin during periods of hypoxia or acidosis resulting in parenchymal ischemia and ultimately tissue necrosis.
24554820
 OTHER
Sickle cell anemia with malaria: a rare case report.
Gupta NK, Gupta M.
Indian J Hematol Blood Transfus. 2014;30(1):38-40.
Sickle cell disease is the prototype of hereditary hemoglobinopathies, characterized by the production of structurally abnormal hemoglobin.
23453001
 MALE Adult
Sudden death in a case of sickle cell anemia: post-mortem computed tomography and autopsy correlation from a radiologist's perspective.
Abdul Rashid SN, Krauskopf A, Vonlanthen B, Thali MJ, Ruder TD.
Leg Med (Tokyo). 2013;15(4):213-6.
Sickle cell anemia (SCA) is a hemolytic disease characterized by the production of abnormal hemoglobin chains and distorted red blood cell morphology or sickling.
17951932
 FEMALE Child
Dental considerations in the management of children suffering from sickle cell disease: a case report.
Ramakrishna Y.
J Indian Soc Pedod Prev Dent. 2007;25(3):140-3.
Sickle cell disease (SCD) is a genetically derived disorder characterized by the presence of an abnormal hemoglobin molecule, designated as hemoglobin S (HbS).
16912855
 FEMALE Adult
Uneventful epidural labor analgesia and vaginal delivery in a parturient with Arnold-Chiari malformation type I and sickle cell disease.
Newhouse BJ, Kuczkowski KM.
Arch Gynecol Obstet. 2007;275(4):311-3.
Sickle cell disease is a disorder of abnormal hemoglobin that is prone to sickling under stressful conditions.
17203426
 FEMALE
Co-existince of sickle cell disease and hemidiaphragm paralysis.
Babayigit C, Melek IM, Duman T, Senyigit A, Gali E.
Tuberk Toraks. 2006;54(4):378-81.
Sickle cell anemia is a disease caused by production of abnormal hemoglobin.
16035582
 FEMALE Middle Aged
Sickle cell anemia patient with sarcoidosis-associated inguinal lymph node and lung infiltration.
Guvenc B, Unsal C, Hanta I, Unsal A, Guvenc H.
J Natl Med Assoc. 2005;97(6):820-2.
Sickle cell anemia (SCA) is the homozygoid form of sickle cell disease (SCD), which includes a group of genetic disorders characterized by production of an abnormal hemoglobin S (HbS).
16035582
 FEMALE Middle Aged
Sickle cell anemia patient with sarcoidosis-associated inguinal lymph node and lung infiltration.
Guvenc B, Unsal C, Hanta I, Unsal A, Guvenc H.
J Natl Med Assoc. 2005;97(6):820-2.
Sickle cell anemia (SCA) is the homozygoid form of sickle cell disease (SCD), which includes a group of genetic disorders characterized by production of an abnormal hemoglobin S (HbS).
11319468
 FEMALE Adult
[Sickle cell anemia and pregnancy: considerations on systematic prophylactic transfusion].
Salque C, Berrebi A, Alie-Daram S, Ayoubi JM, Rigal-Huguet F.
J Gynecol Obstet Biol Reprod (Paris). 2001;30(2):160-5.
Repeated blood transfusions can prevent these complications by reducing the concentration of abnormal hemoglobin S. We report on the evolution of five pregnancies in three patients with sickle cell anemia who received multiple blood transfusions during gestation, and discuss advantages and risks involved in the care of such cases.
8042222
 FEMALE Adult
Effects of total hemoglobin and hemoglobin S concentration on cerebral blood flow during transfusion therapy to prevent stroke in sickle cell disease.
Hurlet-Jensen AM, Prohovnik I, Pavlakis SG, Piomelli S.
Stroke. 1994;25(8):1688-92.
The standard treatment of stroke in sickle cell disease is chronic transfusion to maintain the fraction of abnormal hemoglobin (hemoglobin S [HbS]) below 20%.
1878300
 MALE Adult
An unusual cause of transient ischemic attacks: case report.
Freischlag JA, Machleder HI.
Ann Vasc Surg. 1991;5(4):389-91.
Approximately 20% of children with the SS type sickle cell disease will have cerebrovascular symptoms caused by small intracranial artery occlusion due to sludging of the abnormal hemoglobin.
286037
 MALE Adult
Sickle cell hemoglobinopathies: a protocol for management.
Kinsey RW, Ballard JB, Matukas VJ.
J Oral Surg. 1979;37(6):441-6.
Two cases have been presented: one shows complications when a latent form of sickle cell disease was manifested after orthognathic surgery; the other illustrates a protocol for management of patients with abnormal hemoglobins who are candidates for orthognathic surgery.