Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Fatigue

A subjective feeling of tiredness characterized by a lack of energy and motivation.


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PMID (PMCID)
26171586
 FEMALE Child
Extramedullary hematopoiesis of the liver in a child with sickle cell disease: A rare complication.
Barrier A, Willy S, Slone JS.
Pediatr Int. 2015;57(4):770-2.
We present the case of a 7-year-old Cameroonian girl with sickle cell disease (SCD) who presented with progressive abdominal distension, fever, severe anemia, respiratory distress, and fatigue.
21657139
 MALE Adult
Homozygous sickle cell anemia and secondary complications: a case study.
Yontz CJ, Waller KV.
Clin Lab Sci. 2011;24(2):78-84.
A 26-year-old African-American male presented with chest and back pain, fatigue and a history of the following: homozygous sickle cell anemia, pain crises, stroke, hip replacement following avascular necrosis of the femoral head, priapism, chronic transfusions, iron overload, hypertension, migraine headaches, port infections, depression and type II diabetes.