Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Hypoxemia

An abnormally low level of blood oxygen.


Total: 12

                       


(per page)
PMID (PMCID)
28100970
 MIXED_SAMPLE Infant
Sickle Cell Disease with Cyanotic Congenital Heart Disease: Long-Term Outcomes in 5 Children.
Iannucci GJ, Adisa OA, Oster ME, McConnell M, Mahle WT.
Tex Heart Inst J. 2016;43(6):509-513.
On the basis of this series, we suggest mitigating hypoxemia, and thus the risk of stroke, in patients who have sickle cell disease and cyanotic congenital heart disease.
26917191
 FEMALE Child
Staged Single Ventricle Palliation and Homozygous Sickle Cell Disease.
Maddali MM, Junghare MS, Nishant AR, Kandachar PS, Valliattu J.
J Card Surg. 2016;31(4):237-41.
The successful completion of staged single ventricle palliation in a child with a combination of homozygous sickle cell disease and a single ventricle physiology that tolerate prolonged hypoxemia during earlier stages of Fontan pathway is described.
26917191
 FEMALE Child
Staged Single Ventricle Palliation and Homozygous Sickle Cell Disease.
Maddali MM, Junghare MS, Nishant AR, Kandachar PS, Valliattu J.
J Card Surg. 2016;31(4):237-41.
Hypoxemia is a well-known trigger for precipitating a sickling crisis in patients with sickle cell disease.
18293380
 MIXED_SAMPLE Child
Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea.
Singh SA, Koumbourlis AC, Aygun B.
Pediatr Blood Cancer. 2008;50(6):1258-60.
Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease.
15470216
 MIXED_SAMPLE Infant
Hemoglobin Jamaica plain--a sickling hemoglobin with reduced oxygen affinity.
Geva A, Clark JJ, Zhang Y, Popowicz A, Manning JM, Neufeld EJ.
N Engl J Med. 2004;351(15):1532-8.
A baby girl presented with symptomatic sickle cell disease exacerbated by mild hypoxemia, despite a newborn-screening diagnosis of sickle cell trait.
14982646
 MIXED_SAMPLE Child
Successful treatment of acute chest syndrome with high-frequency oscillatory ventilation in pediatric patients.
Wratney AT, Gentile MA, Hamel DS, Cheifetz IM.
Respir Care. 2004;49(3):263-9.
Severe acute chest syndrome afflicts patients with sickle cell disease and can cause hypoxemia refractory to conventional treatments.
10579281
 MALE
Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent.
Sullivan KJ, Goodwin SR, Evangelist J, Moore RD, Mehta P.
Crit Care Med. 1999;27(11):2563-8.
A 15-yr-old black male with sickle cell disease, bilateral pulmonary infiltrates, refractory hypoxemia, and unstable hemodynamics.
1869989
 MALE Adult
Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia.
Ballas SK, Park CH.
J Nucl Med. 1991;32(8):1617-8.
Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia.
1869989
 MALE Adult
Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia.
Ballas SK, Park CH.
J Nucl Med. 1991;32(8):1617-8.
This article describes a 28-yr-old black man with sickle cell anemia who presented with severe chest pain secondary to acute infarction of the body of the sternum, hypoventilation, and hypoxemia with no evidence of acute chest syndrome.
3408243
 FEMALE Child
Stroke associated with obstructive sleep apnea in a child with sickle cell anemia.
Robertson PL, Aldrich MS, Hanash SM, Goldstein GW.
Ann Neurol. 1988;23(6):614-6.
We describe a child with sickle cell anemia and multiple ischemic infarctions who was found to have severe obstructive sleep apnea and hypoxemia, secondary to adenotonsillar enlargement.
3826133
 MALE Adult
Priapism and dialysis.
Singhal PC, Lynn RI, Scharschmidt LA.
Am J Nephrol. 1986;6(5):358-61.
Additional considerations included dialysis-induced hypoxemia and acidosis which have been known to precipitate priapism in patients with sickle cell disease or trait.
7268869
 MALE
Exchange red blood cell pheresis in a pediatric patient with severe complications of sickle cell anemia.
Kleinman S, Thompson-Breton R, Breen D, Hurvitz C, Goldfinger D.
Transfusion. 1981;21(4):443-6.
This procedure was used in a 13-year-old male with sickle cell anemia, who presented with bilateral pulmonary infiltrates, respiratory distress, and hypoxemia, unresponsive to antibiotics and other means of conservative therapy.