Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).

Total: 9

(per page)

PMID (PMCID)
28717280 (5508441)	OTHER
	Priapism with penile gangrene: An unusual presentation of multiple myeloma.
	Panwar VK, Mavuduru RS, Devana SK, Vaiphei K, Bora GS. Indian J Urol. 2017;33(3):251-252.
	Previous published reports have shown its occurrence in patients with sickle cell disease, urethral carcinoma, bladder carcinoma, thrombotic thrombocytopenic purpura, idiopathic, traumatic, etc.
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	We evaluated 3 patients with renal medullary carcinoma (1 patient with sickle cell disease and 2 patients without sickle cell disease) for germ line and somatic mutations in genes commonly involved in pathogenesis of renal carcinomas using denaturing high-performance liquid chromatography and direct sequencing.
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	Two new mutations in the gene for fumarate hydratase were identified in 1 case of medullary renal carcinoma without sickle cell disease: a germ line mutation in exon 6 (R233H) and an acquired (somatic) mutation in exon 8 (P374S).
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	We evaluated 3 patients with renal medullary carcinoma (1 patient with sickle cell disease and 2 patients without sickle cell disease) for germ line and somatic mutations in genes commonly involved in pathogenesis of renal carcinomas using denaturing high-performance liquid chromatography and direct sequencing.
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	Medullary renal carcinomas from patients with or without sickle cell disease show involvement of genes important in hypoxia-induced signaling pathways.
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	Generalized cellular hypoxia (in sickle cell disease) or pseudohypoxia (in tumors with fumarate hydratase and von Hippel-Lindau mutations or epigenetic silencing) may act alone or in concert at the level of medullary tubular epithelium to promote development of this rare type of renal carcinoma, which could then be genetically reclassified as either fumarate hydratase-associated renal carcinomas or high-grade clear cell renal cell carcinomas.
21733559	MALE	Adult
	Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.
	Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Hum Pathol. 2011;42(12):1979-88.
	Generalized cellular hypoxia (in sickle cell disease) or pseudohypoxia (in tumors with fumarate hydratase and von Hippel-Lindau mutations or epigenetic silencing) may act alone or in concert at the level of medullary tubular epithelium to promote development of this rare type of renal carcinoma, which could then be genetically reclassified as either fumarate hydratase-associated renal carcinomas or high-grade clear cell renal cell carcinomas.
20145663	MALE	Adult
	Renal medullary-like carcinoma in an adult without sickle cell hemoglobinopathy.
	O'Donnell PH, Jensen A, Posadas EM, Bridge JA, Yeldandi AV, Yang XJ, Stadler WM, Al-Ahmadie H. Nat Rev Urol. 2010;7(2):110-4.
	Renal medullary-like carcinoma in an adult without sickle cell trait, sickle cell disease or other hemoglobinopathies.
7942788	MIXED_SAMPLE	Adult
	Bone marrow necrosis.
	Ranaghan L, Morris TC, Desai ZR, Markey GM. Am J Hematol. 1994;47(3):225-8.
	It has been observed during the course of a wide variety of diseases, most commonly in association with acute and chronic leukemia, carcinoma, malignant lymphoma, infections, and sickle cell disease.