Sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

Chest pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.


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(per page)
PMID (PMCID)
30723187
 MALE Adult
Spontaneous Coronary Artery Dissection Masquerading as Coronary Artery Stenosis in a Young Patient.
Rawala MS, Naqvi STS, Yasin M, Rizvi SB.
Am J Case Rep. 2019;20:159-162.
CASE REPORT We present a case of young African American male with sickle cell disease who presented with chest pain associated with shortness of breath.
29498079
 MIXED_SAMPLE Adult
The McConnell Sign is Seen in Patients With Acute Chest Syndrome.
McCutcheon JB, Schaffer P, Lyon M, Gordon R.
J Ultrasound Med. 2018;37(10):2433-2437.
In patients with sickle cell disease presenting with chest pain and shortness of breath, the presence of the McConnell sign does not narrow the differential diagnosis between pulmonary embolism, an acute right ventricular infarct, and acute chest syndrome.
28599856
 MALE
[Bilateral pulmonary embolism mimicking acute chest syndrome in an adolescent with sickle cell disease].
Mornand P, Chalard F, Romain AS, Rohr M, Paluel-Marmont C, Niakate A, Quinet B, Grimprel E, Odievre-Montanie MH.
Arch Pediatr. 2017;24(7):625-629.
We recommend a pulmonary angiography for any chest pain that does not evolve favorably in a child with sickle cell disease.
28599856
 MALE
[Bilateral pulmonary embolism mimicking acute chest syndrome in an adolescent with sickle cell disease].
Mornand P, Chalard F, Romain AS, Rohr M, Paluel-Marmont C, Niakate A, Quinet B, Grimprel E, Odievre-Montanie MH.
Arch Pediatr. 2017;24(7):625-629.
We report on the case of a 17-year-old boy with SS sickle cell disease, admitted for chest pain with dyspnea and tachycardia.
26327979
(4546797)
 FEMALE Adult
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient.
Igala M, Nsame D, Ova JD, Cherkaoui S, Oukkach B, Quessar A.
Pan Afr Med J. 2015;21:142.
We report the case of a 32 years old women admitted for chest pain and haemolysis anemia in which Hashimoto's thyroiditis and sickle cell anemia were found.
23799317
 FEMALE Adult
Chest pain in sickle cell disease.
Tonino SH, Nur E, Otten HM, Wykrzykowska JJ, Hoekstra JB, Biemond BJ.
Neth J Med. 2013;71(5):265-9.
In this manuscript we provide an overview on the various underlying diseases that may cause chest pain in patients with sickle cell disease and provide clues for a proper diagnostic workup.
23799317
 FEMALE Adult
Chest pain in sickle cell disease.
Tonino SH, Nur E, Otten HM, Wykrzykowska JJ, Hoekstra JB, Biemond BJ.
Neth J Med. 2013;71(5):265-9.
Chest pain in sickle cell disease.
22666975
 MALE Adult
Odynophagia in sickle cell anemia: pain is not always a crisis.
Majumder S.
Conn Med. 2012;76(3):155-8.
This report describes the case of a 30-year-old African American male with sickle cell anemia who presented with odynophagia and chest pain.
18176010
 MALE
Bacteroides (Parabacteroides) distasonis splenic abscess in a sickle cell patient.
Al-Tawfiq JA.
Intern Med. 2008;47(1):69-72.
The presence of fever and left sided pleuritic chest pain in patients with sickle cell disease should raise the suspicion of splenic abscess.
16691241
 MALE Adult
Renal medullary carcinoma in a patient with sickle-cell disease.
Sathyamoorthy K, Teo A, Atallah M.
Nat Clin Pract Urol. 2006;3(5):279-83; quiz 289.
A 36-year-old black male with sickle-cell disease, asthma, and dyslipidemia presented with shortness of breath, chest pain, lethargy, and recent fever.
15164390
 FEMALE Adult
Management of acute chest wall sickle cell pain with nebulized morphine.
Ballas SK, Viscusi ER, Epstein KR.
Am J Hematol. 2004;76(2):190-1.
These findings indicate that nebulized morphine may prove effective in the management of acute chest pain in patients with sickle cell anemia.
12934457
 FEMALE Child
[Acute chest syndrome during sickle cell disease: unusual etiology. Apropos of 3 cases with review of the literature].
Ammar J, Ghrairi H, el Mekki F, Aissa I, Hamzaoui A.
Tunis Med. 2003;81(5):345-50.
The Acute Chest Syndrome is a frequent complication of sickle cell disease characterised by chest pain, fever and new infiltrate on chest X ray image.
10367313
 FEMALE Adult
[Acute respiratory distress in a patient with sickle-cell anemia].
Wislez M, Mangiapan G, Saidi F, Parrot A.
Rev Pneumol Clin. 1999;55(1):31-3.
The acute chest syndrome is a frequent complications of sickle-cell disease characterized by chest pain, fever, and new infiltrate on chest x-ray image.
10079887
 MIXED_SAMPLE Child
[Myocardial ischemia: an unknown complication of drepanocytosis in children. Apropos of 2 case reports].
de Pontual L, Acar P, de Montalembert M, Villain E, Maunoury C, Sidi D, Kachaner J.
Arch Pediatr. 1999;6(2):178-81.
Chest pain in children with sickle cell anemia should require ECG and, in case of hypokinetic cardiomyopathy, a myocardial SPECT.
9711198
 MIXED_SAMPLE Adult
Sympathomimetic drug use in adolescents presenting to a pediatric emergency department with chest pain.
James LP, Farrar HC, Komoroski EM, Wood WR, Graham CJ, Bornemeier RA, Valentine JL.
J Toxicol Clin Toxicol. 1998;36(4):321-8.
Exclusion criteria were known diagnoses associated with chest pain (e.g., cardiac disease, sickle cell disease) and major trauma (due to its association with drug use).
8818462
 FEMALE Adult
Impact of bone scintigraphy on the clinical management of a patient with sickle cell anemia and recent chest pain.
Sisayan R, Elgazzar AH, Webner PJ, Religioso DG.
Clin Nucl Med. 1996;21(7):523-6.
Impact of bone scintigraphy on the clinical management of a patient with sickle cell anemia and recent chest pain.
1869989
 MALE Adult
Severe hypoxemia secondary to acute sternal infarction in sickle cell anemia.
Ballas SK, Park CH.
J Nucl Med. 1991;32(8):1617-8.
This article describes a 28-yr-old black man with sickle cell anemia who presented with severe chest pain secondary to acute infarction of the body of the sternum, hypoventilation, and hypoxemia with no evidence of acute chest syndrome.