Dubin-Johnson syndrome

Dubin-Johnson syndrome (DJS) is a benign, inherited liver disorder characterized clinically by chronic, predominantly conjugated, hyperbilirubinemia and histopathologically by black-brown pigment deposition in parenchymal liver cells.

Jaundice

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


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PMID (PMCID)
31016076
 OTHER
A Case of Dubin-Johnson Syndrome in Pregnancy.
Gupta A, Tiwari P, Sachdeva P.
Cureus. 2019;11(2):e4048.
Dubin-Johnson syndrome is an autosomal recessive condition characterized by recurrent episodes of jaundice and conjugated hyperbilirubinemia.
29032691
 MALE Adult
Conjugated hyperbilirubinemia after surgery. A diagnosis of Dubin-Johnson syndrome confirmed by genetic testing.
Baranguan Castro ML, Garcia Romero R, Miramar Gallart MD.
Rev Esp Enferm Dig. 2017;109(11):801-802.
We report the case of a 10 year-old patient who showed, after a surgical procedure for peritonitis due to appendicitis, jaundice and predominantly conjugated hyperbilirubinemia, and he was diagnosed with Dubin-Johnson syndrome by genetic testing.
22544030
 MALE Adult
[A case of sustained cholestasis caused by acute A viral hepatitis in Dubin-Johnson syndrome].
Ra SH, Sung SY, Jung HY, Cha JH, Baik SK, Cho MY, Kim MY.
Korean J Gastroenterol. 2012;59(4):313-6.
Chronic idiopathic jaundice is typical of Dubin-Johnson syndrome and its prognosis is good.
18460254
 MALE Adult
Dubin-Johnson syndrome.
Nisa AU, Ahmad Z.
J Coll Physicians Surg Pak. 2008;18(3):188-9.
Dubin-Johnson syndrome is a benign condition, which results from a hereditary defect in biliary secretion of bilirubin pigments, and manifests as recurrent jaundice with conjugated hyperbilirubinemia.
15565411
 MALE Middle Aged
Improvement of serum bilirubin levels after venesection in a patient with Dubin-Johnson syndrome and HCV-positive chronic liver disease.
Machida I, Wakusawa S, Hayashi H, Suzuki S, Yano M.
J Gastroenterol. 2004;39(9):896-9.
In conclusion, deep jaundice in a patient with Dubin-Johnson syndrome complicated by hepatitis C virus-positive chronic liver disease and iron overload was partially improved by iron-reduction therapy.
12118928
 MALE Adult
Association of Dubin-Johnson syndrome and portal vein thrombosis.
Makharia GK, Garg PK, Gupta SD, Tandon RK.
Indian J Gastroenterol. 2002;21(3):118-9.
We report a 22-year-old man who had recurrent episodes of jaundice (conjugated hyperbilirubinemia) because of Dubin-Johnson syndrome and portal hypertension secondary to portal vein thrombosis.