Melnick-Needles syndrome

Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.

Sclerosis of skull base

Increased bone density of the skull base without significant changes in bony contour.


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PMID (PMCID)
10513069
 FEMALE
Clinical and radiological aspects in Melnick-Needles syndrome.
Albano LM, Kim CA, Lee VK, Sugayama SM, Barba MF, Utagawa CY, Bertola D, Gonzalez CH.
Rev Hosp Clin Fac Med Sao Paulo. 1999;54(2):69-72.
Melnick-Needles syndrome is an X-linked dominant bone dysplasia, lethal in males, characterized by a typical facies and characteristic radiological findings: including sclerosis of skull base and mastoids.