Melnick-Needles syndrome

Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.

Obstructive sleep apnea

A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow.


合計: 4

                       


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PMID (PMCID)
18216701
 FEMALE
Mandibular distraction osteogenesis in a patient with Melnick-Needles syndrome.
Molina FM, Morales C, Taylor JA.
J Craniofac Surg. 2008;19(1):277-9.
To our knowledge, this is the first reported case of mandibular distraction osteogenesis used to cure obstructive sleep apnea and eliminate the need for tracheostomy in a patient with Melnick-Needles syndrome.
16440074
 FEMALE Adult
Melnick-Needles syndrome with obstructive sleep apnea successfully treated with nasal continuous positive airway pressure ventilation.
Lan CC, Hung KF, Liao YF, Lin SW, Chen NH.
J Formos Med Assoc. 2006;105(1):77-9.
Melnick-Needles syndrome with obstructive sleep apnea successfully treated with nasal continuous positive airway pressure ventilation.
16440074
 FEMALE Adult
Melnick-Needles syndrome with obstructive sleep apnea successfully treated with nasal continuous positive airway pressure ventilation.
Lan CC, Hung KF, Liao YF, Lin SW, Chen NH.
J Formos Med Assoc. 2006;105(1):77-9.
We report a 31-year-old female with Melnick-Needles syndrome complicated with severe obstructive sleep apnea syndrome (OSAS).
16919559
 FEMALE Adult
The high-resolution chest CT findings in an adult with Melnick-Needles syndrome.
Harper D, Bloom DA, Rowley JA, Soubani A, Smith WL.
Clin Imaging. 2006;30(5):350-3.
The clinical and physical exam findings also demonstrate an association between Melnick-Needles syndrome and obstructive sleep apnea.