Melnick-Needles syndrome

Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.

Short stature

A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).

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PMID (PMCID)
21274303 (3005751)	FEMALE	Child
	Melnick-Needles syndrome associated with growth hormone deficiency: a case report.
	Akn L, Adal E, Akn MA, Kurtoglu S. J Clin Res Pediatr Endocrinol. 2009;1(5):248-51.
	A six-year-old girl who presented to our clinic with short stature was diagnosed as Melnick-Needles syndrome based upon characteristic clinical and radiological findings.
8831131	MIXED_SAMPLE	Adult
	Melnick-Needles syndrome in a mother and her son.
	Neou P, Kyrkanides S, Gioureli E, Bartsocas CS. Genet Couns. 1996;7(2):123-9.
	The Melnick-Needles syndrome is a rare connective tissue disorder characterised by specific facial features (small facial bones, exophthalmos, hypertelorism, full checks and small mandible), skeletal defects and short stature.