Melnick-Needles syndrome

Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.

Cortical irregularity

An abnormal irregularity of cortical bone.


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PMID (PMCID)
7436151
 FEMALE Child
[Osteodysplasty (Melnick-Needles syndrome) (author's transl)].
de la Cruz Sevilla E, Moscardo LC, Verdu Bellod JF, Lopez Martinez E, Ruiz de la Cuesta F.
An Esp Pediatr. 1980;13(8):704-9.
Authors report a new case of osteodisplasty (Melnick-Needles syndrome) and describe radiological findings that are typical of this entity: bony sclerosis of base structures, abnormal dental alignment, sclerosis and irregularity of clavicles and ribs, described as "band-like" deformity, cortical irregularity of tubular bones with metaphyseal flaring and diaphyseal bowing.