Choroid plexus carcinoma

Choroid plexus carcinoma is a rare and highly aggressive malignant type of choroid plexus tumor (see this term) occurring almost exclusively in children, presenting with cerebrospinal fluid obstruction in the lateral ventricles (most common), the fourth and third ventricles or in multiple ventricles, leading to hydrocephalus and increased intracranial pressure, and manifesting with nausea, vomiting, abnormal eye movements, gait impairment, seizures and enlarged head circumference.

Myelodysplasia

Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.


Total: 2

                      


(per page)
PMID (PMCID)
24251760
MALE Infant
Spitzoid melanoma in a child with Li-Fraumeni syndrome.
Kollipara R, Cooley LD, Horii KA, Hetherington ML, Leboit PE, Singh V, Zwick DL.
Pediatr Dev Pathol. 2014;17(1):64-9.
We report the occurrence of choroid plexus carcinoma, Spitzoid melanoma, and myelodysplasia in a child who was found to carry a germline mutation for TP53.
24251760
MALE Infant
Spitzoid melanoma in a child with Li-Fraumeni syndrome.
Kollipara R, Cooley LD, Horii KA, Hetherington ML, Leboit PE, Singh V, Zwick DL.
Pediatr Dev Pathol. 2014;17(1):64-9.
While choroid plexus carcinoma and myelodysplasia have relatively frequently been described, melanomas have been very rarely described in Li-Fraumeni syndrome.