Choroid plexus carcinoma

Choroid plexus carcinoma is a rare and highly aggressive malignant type of choroid plexus tumor (see this term) occurring almost exclusively in children, presenting with cerebrospinal fluid obstruction in the lateral ventricles (most common), the fourth and third ventricles or in multiple ventricles, leading to hydrocephalus and increased intracranial pressure, and manifesting with nausea, vomiting, abnormal eye movements, gait impairment, seizures and enlarged head circumference.

Ependymoma

The presence of an ependymoma of the central nervous system.


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PMID (PMCID)
25723725
MIXED_SAMPLE Infant
Neoadjuvant chemotherapy for brain tumors in infants and young children.
Iwama J, Ogiwara H, Kiyotani C, Terashima K, Matsuoka K, Iwafuchi H, Morota N.
J Neurosurg Pediatr. 2015;15(5):488-92.
The histopathological diagnoses were ependymoma in 2 patients, anaplastic ependymoma in 1, primitive neuroectodermal tumor (PNET) in 2, choroid plexus carcinoma in 1, atypical teratoid/rhabdoid tumor (AT/RT) in 1, glioblastoma in 1, and embryonal tumor with abundant neuropil and true rosettes in 1.
19915490
MIXED_SAMPLE Infant
Cribriform neuroepithelial tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis.
Hasselblatt M, Oyen F, Gesk S, Kordes U, Wrede B, Bergmann M, Schmid H, Fruhwald MC, Schneppenheim R, Siebert R, Paulus W.
J Neuropathol Exp Neurol. 2009;68(12):1249-55.
Histological and immunohistochemical features did not correspond to established tumor types, including atypical teratoid/rhabdoid tumors, medulloepithelioma, choroid plexus carcinoma, and ependymoma.
19378321
MIXED_SAMPLE Child
Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome.
Rieber J, Remke M, Hartmann C, Korshunov A, Burkhardt B, Sturm D, Mechtersheimer G, Wittmann A, Greil J, Blattmann C, Witt O, Behnisch W, Halatsch ME, Orakcioglu B, von Deimling A, Lichter P, Kulozik A, Pfister S.
Genes Chromosomes Cancer. 2009;48(7):558-68.
The father of this patient was diagnosed with myxopapillary ependymoma (WHO degrees I), whereas a brother died from an early relapse of a choroid plexus carcinoma.
12845541
MIXED_SAMPLE Infant
Surgical approach to the fourth ventricle cavity through the cerebellomedullary fissure.
Gok A, Alptekin M, Erkutlu I.
Neurosurg Rev. 2004;27(1):50-4.
The patients had various pathologies including hemangioblastoma, epidermoid tumor, medulloblastoma, ependymoma, low grade astrocytoma, choroid plexus carcinoma, choroid plexus papilloma, adenocarcinoma in the pons, and cavernoma in the medulla.
9185218
MIXED_SAMPLE Infant
"Polyphenotypic" tumors in the central nervous system: problems in nosology and classification.
Jay V, Edwards V, Halliday W, Rutka J, Lau R.
Pediatr Pathol Lab Med. 1997;17(3):369-89.
The histological and ultrastructural appearances were inconsistent with glioma, PNET, meningioma, ependymoma, choroid plexus carcinoma, sarcoma, germ cell tumor, and other tumors in the World Health Organization classification.
8851949
MIXED_SAMPLE Adult
[Hemocirculation and metabolism in intraventricular tumors: kinetic analysis of glucose metabolism].
Shioya H, Mineura K, Kowada M, Iida H, Murakami M, Ogawa T, Hatazawa J, Uemura K.
No Shinkei Geka. 1996;24(3):211-9.
Histological diagnosis was as follows: five cases of central neurocytoma, one subependymal giant cell astrocytoma, one ependymoma, one choroid plexus carcinoma, one subependymoma, and one meningioma.
3863432
MALE Infant
Choroid plexus carcinoma. Report of a case with cytopathologic differential diagnosis.
Kim K, Greenblatt SH, Robinson MG.
Acta Cytol. 1985;29(5):846-9.
The cytologic features of the choroid plexus carcinoma (tight spatial clusters and isolated anaplastic cells with striking nuclear lobulation) were distinct from those of lymphoma, leukemia, neuroblastoma, ependymoma and pineal germinoma.