Pachydermoperiostosis

Pachydermoperiostosis (PDP) is a form of primary hypertrophic osteoarthropathy (see this term), a rare hereditary disorder, and is characterized by digital clubbing, pachydermia and subperiosteal new bone formation associated with pain, polyarthritis, <i>cutis verticis gyrata</i>, seborrhea and hyperhidrosis. Three forms have been described: a complete form with pachydermia and periostitis, an incomplete form with evidence of bone abnormalities but lacking pachydermia, and a <i>forme frusta</i> with prominent pachydermia and minimal-to-absent skeletal changes.

Hepatitis

Inflammation of the liver.

Total: 4

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PMID (PMCID)
29514715 (5842528)	MALE	Young Adult
	Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.
	Atiase Y, Yorke E, Akpalu J, Opoku-Asare B, Adjei P, Amissah-Arthur MB, Akpalu A. J Med Case Rep. 2018;12(1):59.
	We do not imply a causal relationship between pachydermoperiostosis and hepatitis B infection because pachydermoperiostosis is a genetic disorder; however, the question is raised whether hypertrophic osteoarthropathy is one of the many extrahepatic manifestations of chronic hepatitis B infection.
29514715 (5842528)	MALE	Young Adult
	Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.
	Atiase Y, Yorke E, Akpalu J, Opoku-Asare B, Adjei P, Amissah-Arthur MB, Akpalu A. J Med Case Rep. 2018;12(1):59.
	The possible role of hepatitis B in hypertrophic osteoarthropathy, that is, secondary hypertrophic osteoarthropathy, needs to be explored; however, with digital clubbing in his father our patient is likely to have pachydermoperiostosis.
29514715 (5842528)	MALE	Young Adult
	Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.
	Atiase Y, Yorke E, Akpalu J, Opoku-Asare B, Adjei P, Amissah-Arthur MB, Akpalu A. J Med Case Rep. 2018;12(1):59.
	Vascular endothelial growth factors which have been implicated in the clinical features of pachydermoperiostosis, have also been shown to be present in chronic hepatitis and implicated in the malignant transformation of hepatitis B infection to hepatocellular carcinoma.
29514715 (5842528)	MALE	Young Adult
	Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.
	Atiase Y, Yorke E, Akpalu J, Opoku-Asare B, Adjei P, Amissah-Arthur MB, Akpalu A. J Med Case Rep. 2018;12(1):59.
	We do not imply a causal relationship between pachydermoperiostosis and hepatitis B infection because pachydermoperiostosis is a genetic disorder; however, the question is raised whether hypertrophic osteoarthropathy is one of the many extrahepatic manifestations of chronic hepatitis B infection.