Congenital rubella syndrome

Congenital rubella syndrome (CRS) is an infectious embryofetopathy that may present in an infant as a result of maternal infection and subsequent fetal infection with rubella virus. CRS can lead to deafness, cataract, and variety of other permanent manifestations including cardiac and neurological defects.

Cataract

A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.


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PMID (PMCID)
27220231
(5712918)
 MALE
Secondary congenital aphakia.
Ionescu C, Dascalescu D, Cristea M, Schmitzer S, Cioboata M, Iancu R, Corbu C.
Rom J Ophthalmol. 2016;60(1):37-9.
A 2-year-old patient, diagnosed with congenital rubella syndrome including sensorineural deafness, congenital heart disease, intellectual disability, microcephaly, microphthalmia, and congenital cataract, presented to our clinic for the surgical treatment of cataract.
27220231
(5712918)
 MALE
Secondary congenital aphakia.
Ionescu C, Dascalescu D, Cristea M, Schmitzer S, Cioboata M, Iancu R, Corbu C.
Rom J Ophthalmol. 2016;60(1):37-9.
A 2-year-old patient, diagnosed with congenital rubella syndrome including sensorineural deafness, congenital heart disease, intellectual disability, microcephaly, microphthalmia, and congenital cataract, presented to our clinic for the surgical treatment of cataract.
24210344
 MALE Infant
Transient leopard spot corneal endothelial staining with trypan blue during cataract surgery in a child with congenital rubella syndrome.
Baldwin A, Risma J, Longmuir S.
J AAPOS. 2013;17(6):629-31.
Transient leopard spot corneal endothelial staining with trypan blue during cataract surgery in a child with congenital rubella syndrome.
22490421
 MALE Adult
Unilateral pulmonary artery stenosis and late-onset cataract in an adult: a case of suspected congenital rubella syndrome.
Liu Y, Guo J, Zhao RF, Wang L.
Chin Med J (Engl). 2012;125(3):549-51.
Unilateral pulmonary artery stenosis and late-onset cataract in an adult: a case of suspected congenital rubella syndrome.
22490421
 MALE Adult
Unilateral pulmonary artery stenosis and late-onset cataract in an adult: a case of suspected congenital rubella syndrome.
Liu Y, Guo J, Zhao RF, Wang L.
Chin Med J (Engl). 2012;125(3):549-51.
However, we report a rare case of suspected congenital rubella syndrome in an adult with unilateral pulmonary artery stenosis and late-onset cataract.
22490421
 MALE Adult
Unilateral pulmonary artery stenosis and late-onset cataract in an adult: a case of suspected congenital rubella syndrome.
Liu Y, Guo J, Zhao RF, Wang L.
Chin Med J (Engl). 2012;125(3):549-51.
Congenital rubella syndrome is characterized by the triad of deafness, cataract and cardiovascular malformations.
16084344
 MALE Adult
Aortic hypoplasia and right ventricular outflow tract obstruction in a young man with uncontrolled hypertension.
Ho E, Foley DP, Brown A.
J Am Soc Echocardiogr. 2005;18(8):883.
A possible unifying diagnosis, with the combination of aortic hypoplasia, pulmonary artery stenosis, patent ductus arteriosus, and cataracts, was believed to have been congenital rubella syndrome.
11213556
 MIXED_SAMPLE Infant, Newborn
[Congenital infection: diagnostic serology of the mother not always definitive].
Verboon-Maciolek MA, Gerards LJ, Stoutenbeek P, van Loon AM.
Ned Tijdschr Geneeskd. 2001;145(4):153-6.
The infants were born with typical symptoms of multisystem disease, known as symptomatic congenital cytomegalovirus infection (jaundice, petechiae, hepatosplenomegaly, intrauterine growth retardation, microcephaly and cerebral calcifications) and congenital rubella syndrome (intrauterine growth retardation, congenital heart disease, cataract, hepatosplenomegaly and cerebral calcifications), respectively.