POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Membranoproliferative glomerulonephritis

A type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity


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PMID (PMCID)
28291506
FEMALE Adult
Immunotactoid glomerulopathy leading to the discovery of POEMS syndrome
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Philipponnet C, Kemeny JL, Garrouste C, Soubrier M, Heng AE.
Clin Nephrol. 2017;87(6):310-315.
Renal involvement in POEMS syndrome typically exhibits a thrombotic microangiopathy-like membranoproliferative glomerulonephritis appearance associated with endothelial lesions stigmata.
8072225
FEMALE Adult
[A case of Crow-Fukase syndrome associated with membranoproliferative glomerulonephritis].
Takeshita S, Yamakado M, Nagano M, Umezu M, Tagawa H.
Nihon Jinzo Gakkai Shi. 1994;36(7):858-62.
[A case of Crow-Fukase syndrome associated with membranoproliferative glomerulonephritis].