POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Diabetes mellitus

A group of abnormalities characterized by hyperglycemia and glucose intolerance.


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PMID (PMCID)
10596729
 MALE Middle Aged
Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus.
Mano T, Mori K, Sawai Y, Oda N, Tugawa T, Nakano I, Watanabe F, Hamada M, Nakai A, Yamamoto H, Harada N, Nagasaka A, Itoh M.
Endocr Res. 1999;25(3-4):371-80.
Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus.
10596729
 MALE Middle Aged
Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus.
Mano T, Mori K, Sawai Y, Oda N, Tugawa T, Nakano I, Watanabe F, Hamada M, Nakai A, Yamamoto H, Harada N, Nagasaka A, Itoh M.
Endocr Res. 1999;25(3-4):371-80.
We report a patient with the Crow-Fukase syndrome who exhibited non-insulin dependent diabetes mellitus (NIDDM) worsened prior to admission.
10074579
 MALE Adult
POEMS syndrome, steroid-dependent diabetes mellitus, erythema elevatum diutinum, and rheumatoid arthritis as extramedullary manifestations of plasma cell dyscrasia.
Albitar S, Bourgeon B, Genin R, Jacquesson M, Riviere JP, Serveaux MO, Ribera A, Serveaux JP.
Am J Kidney Dis. 1998;31(4):E3.
POEMS syndrome, steroid-dependent diabetes mellitus, erythema elevatum diutinum, and rheumatoid arthritis as extramedullary manifestations of plasma cell dyscrasia.
10074579
 MALE Adult
POEMS syndrome, steroid-dependent diabetes mellitus, erythema elevatum diutinum, and rheumatoid arthritis as extramedullary manifestations of plasma cell dyscrasia.
Albitar S, Bourgeon B, Genin R, Jacquesson M, Riviere JP, Serveaux MO, Ribera A, Serveaux JP.
Am J Kidney Dis. 1998;31(4):E3.
We thus concluded that POEMS syndrome, steroid-dependent diabetes mellitus, rheumatoid arthritis, RA, and skin vasculitis in our patient were triggered by plasma cell dyscrasia.
10074579
 MALE Adult
POEMS syndrome, steroid-dependent diabetes mellitus, erythema elevatum diutinum, and rheumatoid arthritis as extramedullary manifestations of plasma cell dyscrasia.
Albitar S, Bourgeon B, Genin R, Jacquesson M, Riviere JP, Serveaux MO, Ribera A, Serveaux JP.
Am J Kidney Dis. 1998;31(4):E3.
We herein report the atypical case of a 44-year-old white man presenting with glomerulopathy, POEMS syndrome, and erythema elevatum diutinum with a few-year history of non-insulin-dependent diabetes mellitus (NIDDM) and seronegative rheumatoid arthritis (RA) as early manifestations of IgAlambda multiple myeloma.
8539476
 FEMALE Middle Aged
POEMS syndrome in a female Italian patient. A case report.
Bertola G, Torchio G, Mattioli M, Bocchia M, Meregalli M.
Recenti Prog Med. 1995;86(11):442-4.
POEMS syndrome is an uncommon association of polyneuropathy, organomegaly (liver, spleen, lymph nodes), endocrinopathy (hypogonadism primary hypothyroidism, diabetes mellitus, adrenal insufficiency), monoclonal gammopathy and skin changes; bone lesions (generally osteosclerotic, less frequently osteolytic or mixed) are nearly always present in this multisystem disease.