POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Hypothyroidism

Deficiency of thyroid hormone.


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PMID (PMCID)
27401385
 FEMALE Adult
[Chronic kidney disease associated with Poems syndrome: Report of one case].
Vega J.
Rev Med Chil. 2016;144(4):516-20.
We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castlemans disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea.
26634133
(4664845)
 OTHER
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome.
Kumar S, Sharma S.
Oxf Med Case Reports. 2015;2015(3):237-40.
We report a case of POEMS syndrome who presented with insidious onset, progressive sensorimotor polyneuropathy, pedal edema, ascites, hepatomegaly, skin changes and hypothyroidism.
16550137
 FEMALE
Multiple cutaneous angiomas and Poems syndrome.
Granel B, Serratrice J, de Roux-Serratrice C, Ene N, Disdier P, Weiller PJ.
Presse Med. 2006;35(3 Pt 1):430-2.
Other manifestations of Poems syndrome in this patient included endocrine dysfunction (hypothyroidism, adrenal insufficiency, and hypogonadism), sclerotic bone lesions of the femoral shaft, ribs, and vertebral body, monoclonal gammopathy, and anasarca.
17072808
 FEMALE Adult
[Bilateral papilloedema as the initial symptom of POEMS syndrome].
Marti-Martinez S, Martin-Estefania C, Turpin-Fenoll L, Pampliega-Perez A, Reus-Banuls S, Garcia-Barragan N, Villarubia-Lor B.
Rev Neurol. 2006;43(9):531-4.
Two years later the patient had hepatomegaly, subclinical hypothyroidism and sclerodermiform alterations of the skin, which suggested a probable diagnosis of POEMS syndrome that was later confirmed by the presence of monoclonal component in blood and urine.
16307346
 MALE Middle Aged
An atypical case of POEMS syndrome with IgG kappa M protein and end stage renal failure.
Dursun B, Artac M, Varan HI, Akkaya BK, Karpuzoglu G, Suleymanlar G.
Int Urol Nephrol. 2005;37(3):581-5.
Here, we presented an atypical case of POEMS syndrome with IgG kappa monoclonal protein, chronic demyelinating polyneuropathy, hepatosplenomegaly, hypothyroidism, gynecomastia and severe renal impairment.
15678710
 FEMALE Middle Aged
Calciphylaxis in a patient with POEMS syndrome without renal failure and/or hyperparathyroidism. A case report.
De Roma I, Filotico R, Cea M, Procaccio P, Perosa F.
Ann Ital Med Int. 2004;19(4):283-7.
Two and a half years earlier, a POEMS syndrome had been diagnosed on the basis of a history of organomegaly and mild lymphadenopathy, IgA-lambda monoclonal gammopathy, hypothyroidism, severe lower and upper limb sensory-motor peripheral neuropathy and a single osteosclerotic lesion in the left humerus.
15884463
 MALE Middle Aged
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome.
Kumar P, Verma A, Kishore D, Parhi LD, Joshi D, Misra S.
J Assoc Physicians India. 2004;52:997-8.
A 55-years-old male, who presented with insidious onset gradually progressive sensorimotor polyneuropathy, POEMS-syndrome was diagnosed based on polyneuropathy, splenomegaly, hypothyroidism, the presence of IgG-monoclonal serum protein with osteosclerotic lesions and hyperpigmention of skin.
11876037
 MALE Middle Aged
[A man with plasma cell dyscrasia and polyneuropathy due to POEMS syndrome].
Driessens SK, Wildiers H, Verhoef GE, Vanstraelen D, Robberecht W, Vandenberghe P.
Ned Tijdschr Geneeskd. 2002;146(7):321-5.
In a 52-year-old man with general malaise, muscle stiffness and weakness, POEMS-syndrome was diagnosed based on polyneuropathy, splenomegaly, lymphadenopathy, subclinical hypothyroidism and the presence of a monoclonal paraprotein with osteosclerotic lesions and an indurated skin (POEMS is an acronym for Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes).
10391973
 FEMALE Middle Aged
[Crow-Fukase syndrome associated with Castleman disease showing hypertrophic cranial pachymeningitis and bilateral internal carotid artery occlusion].
Hori T, Tsuboi Y, Okubo R, Hirooka M, Yamada T.
Rinsho Shinkeigaku. 1999;39(4):456-60.
A 51-year-old woman was diagnosed as Crow-Fukase syndrome on July 1997, presenting with lymph node swelling, polyneuropathy, hepatomegaly, hypothyroidism, renal dysfunction, edema and skin change.
8962962
 MIXED_SAMPLE Middle Aged
[The POEMS syndrome, apropos of 2 cases and review of the literature].
de la Pena A, Subtil JC, Rodriguez-Rosado R, Yuste JR, Lucas I.
An Med Interna. 1996;13(6):291-4.
We describe two cases of POEMS syndrome, both with polyneuropathy, monoclonal gammopathy of the IgG lambda type, thickening of the skin with Raynaud phenomenon, multiple osteosclerotic lesions and hypothyroidism.