POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Adrenal insufficiency

Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.


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PMID (PMCID)
27401385
 FEMALE Adult
[Chronic kidney disease associated with Poems syndrome: Report of one case].
Vega J.
Rev Med Chil. 2016;144(4):516-20.
We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castlemans disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea.
19295942
 FEMALE Adult
Spontaneous recovery of adrenal insufficiency in POEMS syndrome.
Ashawesh K, Fiad TM.
Medscape J Med. 2009;11(1):21.
We report the first case of spontaneous recovery of adrenal insufficiency in a patient with POEMS syndrome treated with autologous hematopoietic cell transplantation.
19295942
 FEMALE Adult
Spontaneous recovery of adrenal insufficiency in POEMS syndrome.
Ashawesh K, Fiad TM.
Medscape J Med. 2009;11(1):21.
Spontaneous recovery of adrenal insufficiency in POEMS syndrome.
19295942
 FEMALE Adult
Spontaneous recovery of adrenal insufficiency in POEMS syndrome.
Ashawesh K, Fiad TM.
Medscape J Med. 2009;11(1):21.
We conclude that in patients with POEMS syndrome, adrenal insufficiency should be regularly assessed for potential recovery.
16550137
 FEMALE
Multiple cutaneous angiomas and Poems syndrome.
Granel B, Serratrice J, de Roux-Serratrice C, Ene N, Disdier P, Weiller PJ.
Presse Med. 2006;35(3 Pt 1):430-2.
Other manifestations of Poems syndrome in this patient included endocrine dysfunction (hypothyroidism, adrenal insufficiency, and hypogonadism), sclerotic bone lesions of the femoral shaft, ribs, and vertebral body, monoclonal gammopathy, and anasarca.
8539476
 FEMALE Middle Aged
POEMS syndrome in a female Italian patient. A case report.
Bertola G, Torchio G, Mattioli M, Bocchia M, Meregalli M.
Recenti Prog Med. 1995;86(11):442-4.
POEMS syndrome is an uncommon association of polyneuropathy, organomegaly (liver, spleen, lymph nodes), endocrinopathy (hypogonadism primary hypothyroidism, diabetes mellitus, adrenal insufficiency), monoclonal gammopathy and skin changes; bone lesions (generally osteosclerotic, less frequently osteolytic or mixed) are nearly always present in this multisystem disease.