POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Clubbing

Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails.

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PMID (PMCID)
27401385	FEMALE	Adult
	[Chronic kidney disease associated with Poems syndrome: Report of one case].
	Vega J. Rev Med Chil. 2016;144(4):516-20.
	We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castlemans disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea.
21301037	MIXED_SAMPLE	Middle Aged
	[Crow-Fukase syndrome (POEMS syndrome)].
	Iwashita H. Brain Nerve. 2011;63(2):131-9.
	In 1956, Crow reported the British case of a 54-year-old man with osteosclerotic myeloma, polyneuropathy, edema, skin hyperpigmentation, clubbed fingers, white nails, and lymphadenopathy.
8286834	FEMALE	Middle Aged
	Crow-Fukase syndrome associated with pulmonary hypertension.
	Iwasaki H, Ogawa K, Yoshida H, Takashima F, Shimizu K, Lee JD, Ueda T, Nakamura T. Intern Med. 1993;32(7):556-60.
	These findings suggest the possibility that patients with Crow-Fukase syndrome have cardiopulmonary disorders including PH and cardiomegaly which might cause some cardiovascular symptoms such as peripheral edema and finger clubbing.
1295088	MALE	Adult
	POEMS syndrome with myocardial infarction: observations concerning pathogenesis and review of the literature.
	Manning WJ, Goldberger AL, Drews RE, Goldstein BJ, Matheson JK, Rabinowe SL, Trentham DE, Landsberg L. Semin Arthritis Rheum. 1992;22(3):151-61.
	A diagnosis of POEMS syndrome was made based on the clinical presentation; additional physical findings of papilledema, clubbing, and hyperpigmentation; and laboratory findings of an immunoglobulin G M component of the lambda subtype, elevated cerebrospinal fluid protein, and typical sclerotic bone lesions.