POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Confusion

Lack of clarity and coherence of thought, perception, understanding, or action.


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PMID (PMCID)
3954805
 MALE Adult
POEMS syndrome. Study of a patient with proteinuria, microangiopathic glomerulopathy, and renal enlargement.
Fam AG, Rubenstein JD, Cowan DH.
Arthritis Rheum. 1986;29(2):233-41.
The latter finding is unusual in POEMS syndrome patients, and the associated symptoms can lead to confusion in diagnosis.