POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


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PMID (PMCID)
8894744
 FEMALE Adult
Development of secondary leukemia associated with (1;7)(q10;p10) in a patient with Crow-Fukase syndrome.
Satoh K, Miura I, Chubachi A, Utsumi S, Imai H, Miura AB.
Intern Med. 1996;35(8):660-2.
Because of the risk of therapy-related leukemia, alkylating agents should be used with caution in the treatment of Crow-Fukase syndrome.