POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Headache

Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.


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PMID (PMCID)
26077937
 FEMALE Adult
Ventriculoperitoneal shunt placement for POEMS syndrome.
Alvarez-Breckenridge CA, Attiah MA, Zachariah M, Gummadavelli A, Yang J, Codd PJ.
J Clin Neurosci. 2015;22(10):1672-4.
With extensive workup she was diagnosed with POEMS syndrome with progressive headaches, visual loss with papilledema, and repeated elevated lumbar puncture opening pressures despite treatment with acetazolamide and immunosuppressive therapy.