POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Lymphadenopathy

Enlargment (swelling) of a lymph node.


Total: 16

                       


(per page)
PMID (PMCID)
29113155
(5656028)
 OTHER
POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report.
Cao CJ, Dou CY, Zhou KH, Liu JB, Lai H.
Oncol Lett. 2017;14(5):5197-5202.
A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typically955-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss.
29113155
(5656028)
 OTHER
POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report.
Cao CJ, Dou CY, Zhou KH, Liu JB, Lai H.
Oncol Lett. 2017;14(5):5197-5202.
A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typically955-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss.
27401385
 FEMALE Adult
[Chronic kidney disease associated with Poems syndrome: Report of one case].
Vega J.
Rev Med Chil. 2016;144(4):516-20.
We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castlemans disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea.
21301037
 MIXED_SAMPLE Middle Aged
[Crow-Fukase syndrome (POEMS syndrome)].
Iwashita H.
Brain Nerve. 2011;63(2):131-9.
In 1956, Crow reported the British case of a 54-year-old man with osteosclerotic myeloma, polyneuropathy, edema, skin hyperpigmentation, clubbed fingers, white nails, and lymphadenopathy.
21915731
 MALE Middle Aged
[POEMS syndrome. An interdisciplinary clinical challenge].
Braun SA, Albrecht P, Methner A, Hanneken S.
Hautarzt. 2011;62(10):722-5.
In addition to the skin changes, the patient was diagnosed with polyneuropathy, monoclonal gammopathy (type lambda), high elevated VEGF-levels, hepatomegaly, lymphadenopathy, hypothyreosis, hypogonadism and thrombocytosis in the course of POEMS syndrome.
19546057
 MALE Middle Aged
Pituitary macroadenoma in a patient with POEMS syndrome in conjunction with Castleman disease: first report of a case and review of related literature.
Bruno C, Fleck JD, Cavaghan MK.
Endocr Pract. 2010;16(1):97-101.
He also had diffuse lymphadenopathy, monoclonal gammopathy, and skin lesions consistent with a diagnosis of POEMS syndrome.
19670534
 MALE Child
Poems syndrome--a rare variant of plasma cell dyscrasia. Case report and review of literature.
Goranova-Marinova VS, Chernev KG, Goranov SE.
Folia Med (Plovdiv). 2009;51(2):5-11.
We present a case of POEMS syndrome in a 47-year-old male patient who initially presented with edema of the lower limbs, moderate lymphadenopathy, hepatosplenomegaly, histological findings of Castleman disease with marked sinusoidal angioproliferation in the lymph nodes and multiple osteosclerotic lesions.
15991840
 MIXED_SAMPLE Middle Aged
Idiopathic multicentric Castleman's disease. A clinicopathologic and immunohistochemical study of five cases.
Kojima M, Nakamura S, Nishikawa M, Itoh H, Miyawaki S, Masawa N.
Pathol Res Pract. 2005;201(4):325-32.
These include HIV infection, autoimmune-disease-associated lymphadenopathy, idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia, "idiopathic MCD", POEMS syndrome (polyneuropathy, anasarca, organomegaly, endocrinopathy, M-proteins, and skin lesions), and non-Hodgkin's lymphomas.
15991840
 MIXED_SAMPLE Middle Aged
Idiopathic multicentric Castleman's disease. A clinicopathologic and immunohistochemical study of five cases.
Kojima M, Nakamura S, Nishikawa M, Itoh H, Miyawaki S, Masawa N.
Pathol Res Pract. 2005;201(4):325-32.
These include HIV infection, autoimmune-disease-associated lymphadenopathy, idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia, "idiopathic MCD", POEMS syndrome (polyneuropathy, anasarca, organomegaly, endocrinopathy, M-proteins, and skin lesions), and non-Hodgkin's lymphomas.
15678710
 FEMALE Middle Aged
Calciphylaxis in a patient with POEMS syndrome without renal failure and/or hyperparathyroidism. A case report.
De Roma I, Filotico R, Cea M, Procaccio P, Perosa F.
Ann Ital Med Int. 2004;19(4):283-7.
Two and a half years earlier, a POEMS syndrome had been diagnosed on the basis of a history of organomegaly and mild lymphadenopathy, IgA-lambda monoclonal gammopathy, hypothyroidism, severe lower and upper limb sensory-motor peripheral neuropathy and a single osteosclerotic lesion in the left humerus.
15293761
 FEMALE Middle Aged
[A case of Crow-Fukase syndrome showing improvement following excision and irradiation of bone lesions].
Yoritaka A, Sakai M, Ohta K, Kishida S.
Rinsho Shinkeigaku. 2004;44(6):369-71.
A 57-year-old woman suffering from pleural and pericardial effusion, pulmonary hypertention, lymphadenopathy, hepatosplenomegaly, edema, hypertrichosis, small hemangioma and polyneuropathy was diagnosed as Crow-Fukase syndrome.
15552541
 MALE Adult
[Transitional type of Castleman's disease manifested as the POEMS syndrome].
Tomic I, Plavec G, Tasic O, Ristanovic A, Cvijanovic V.
Vojnosanit Pregl. 2004;61(4):439-44.
The simultaneous presence of these manifestations of the disease (sensomotor peripheral neuropathy, lymphadenopathy, effusions, endocrinopathy, polyclonal gammaglobulinemia and skin changes) is indentified as POEMS syndrome.
11876037
 MALE Middle Aged
[A man with plasma cell dyscrasia and polyneuropathy due to POEMS syndrome].
Driessens SK, Wildiers H, Verhoef GE, Vanstraelen D, Robberecht W, Vandenberghe P.
Ned Tijdschr Geneeskd. 2002;146(7):321-5.
In a 52-year-old man with general malaise, muscle stiffness and weakness, POEMS-syndrome was diagnosed based on polyneuropathy, splenomegaly, lymphadenopathy, subclinical hypothyroidism and the presence of a monoclonal paraprotein with osteosclerotic lesions and an indurated skin (POEMS is an acronym for Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes).
8180908
 MALE Adult
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome.
Milanov I, Georgiev D.
Can J Neurol Sci. 1994;21(1):60-3.
A patient with a three year history of POEMS syndrome-polyneuropathy, hepatosplenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described.
8180908
 MALE Adult
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome.
Milanov I, Georgiev D.
Can J Neurol Sci. 1994;21(1):60-3.
A patient with a three year history of POEMS syndrome-polyneuropathy, hepatosplenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described.
2276681
 MALE Middle Aged
POEMS syndrome: a case report.
Bisail M, Cossu A, Massarelli G, Tanda F, Agnetti V, Traccis S, Cassisa L, Puliga MV, Bartoli E.
Haematologica. 1990;75(4):384-6.
A case of POEMS syndrome in a 43-year-old male with polyneuropathy, osteolytic lesion of the basin due to solitary IgA-lambda plasmacytoma, cutaneous scleroderma-like changes, diffuse lymphadenopathy and hepatosplenomegaly is described.