POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Axonal loss

A reduction in the number of axons in the peripheral nervous system.


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PMID (PMCID)
21982617
 FEMALE Adult
POEMS syndrome with prominent acute axonal lesions.
Mathis S, Magy L, Kabore R, Faugeras F, Richard L, Vallat JM.
J Neurol Sci. 2012;313(1-2):185-8.
POEMS syndrome is usually associated with demyelinating neuropathy (and secondary axonal loss); however, prominent axonal neuropathy (with acute axonal lesions on nerve biopsy) can also be observed in this disease.