POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Mild proteinuria

Mildly increased levels of protein in the urine (150-500 mg per day in adults).


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PMID (PMCID)
11434361
 MALE Adult
Association of a POEMS syndrome and light chain deposit disease: first case report.
Lambotte O, Durrbach A, Ammor M, Paradis V, Djeffal R, Machover D, Charpentier B.
Clin Nephrol. 2001;55(6):482-6.
In POEMS syndrome, renal abnormalities are rare and are reported as a moderate renal insufficiency with mild proteinuria or acute functional renal insufficiency leading in some cases to end-stage renal failure [Fukatsu et al.