POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Asthenia

A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.


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PMID (PMCID)
9767755
 MALE Middle Aged
[POEMS syndrome with primary adrenocortical insufficiency].
Mauvais-Jarvis F, Bertherat J, Ravaud H, Thomopoulos P, Luton JP.
Presse Med. 1998;27(1):15-7.
A patient with POEMS syndrome developed primary adrenocortical deficiency revelated by asthenia and hyperpigmentation.
9767755
 MALE Middle Aged
[POEMS syndrome with primary adrenocortical insufficiency].
Mauvais-Jarvis F, Bertherat J, Ravaud H, Thomopoulos P, Luton JP.
Presse Med. 1998;27(1):15-7.
Although asthenia and skin pigmentation are common in POEMS syndrome, adrenocortical deficiency is seldom reported.