POEMS syndrome

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Gastric varix

Extreme dilation of the submucusoal veins in the stomach.


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(per page)
PMID (PMCID)
28503308
(5425989)
 OTHER
Portal hypertension as the initial manifestation of POEMS syndrome: a case report.
Wu L, Li Y, Yao F, Lu C, Li J, Zhou W, Qian J.
BMC Hematol. 2017;17:9.
Lenalidomide with or without dexamethasone is effective for portal hypertension due to POEMS syndrome, though esophageal and gastric varices seems not reversible so easily.