Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Renal insufficiency

A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.


Total: 30

                      


(per page)
PMID (PMCID)
30117481
(6198690)
OTHER
Proptosis and hemiplegia as an initial manifestation of multiple myeloma.
Tahiliani N, Kataria P, Patel A, Kendre P.
J Postgrad Med. 2018;64(4):243-246.
Multiple myeloma (MM) is a monoclonal gammopathy, also known as the malignant proliferation of plasma cells, presenting with typical complications such as hypercalcemia, osteolytic bone lesions, anemia, renal insufficiency, and frequent infections.
27099330
MALE
I.V. ascorbic acid for treatment of apparent rasburicase-induced methemoglobinemia in a patient with acute kidney injury and assumed glucose-6-phosphate dehydrogenase deficiency.
Reeves DJ, Saum LM, Birhiray R.
Am J Health Syst Pharm. 2016;73(9):e238-42.
A 46-year-old African-American man with a recent diagnosis of multiple myeloma and renal insufficiency was admitted to the hospital with a cough, hemoptysis, and fatigue.
25372546
MALE Adult
Resolution of bilateral cystoid macular edema and subfoveal serous retinal detachments after treatment with bortezomib in a patient with "smoldering" multiple myeloma.
Grannis CH, Dewan VN, Wang RC.
Retin Cases Brief Rep. 2014;8(4):348-51.
Before treatment with bortezomib and dexamethasone, the patient had complaints of confusion, muscle stiffness, joint pain, and 20-lb unintentional weight loss; however, he did not have hypercalcemia, renal insufficiency, anemia, or bone lesions typical of active multiple myeloma.
23709144
MALE Middle Aged
Multiple solitary plasmacytoma with multifocal bone involvement. First clinical case report in a uraemic patient.
Dattolo P, Allinovi M, Michelassi S, Pizzarelli F.
BMJ Case Rep. 2013;2013:.
It differs from multiple myeloma by the lack of hypercalcaemia, renal insufficiency, anaemia and pathological monoclonal plasmocytosis on a random bone biopsy.
22889516
MIXED_SAMPLE Adult
Use of continuous venovenous hemofiltration for acute renal failure due to multiple myeloma cast nephropathy.
Mehta S, Shtaynberg N, Goldman M, Asti D, Kiroycheva M, Pepe J.
Hematology. 2012;17(4):229-31.
Renal insufficiency is associated with high morbidity and mortality in multiple myeloma.
20134391
MALE Middle Aged
Multiple myeloma presenting as recurrent sinopulmonary infections.
Kang J, Kumar A, Monteleone C.
South Med J. 2010;103(3):260-1.
Multiple myeloma is a plasma cell malignancy that classically presents with bone pain secondary to osteolytic lesions, anemia, and renal insufficiency.
20360121
MIXED_SAMPLE Middle Aged
New tools for detecting occult monoclonal gammopathy, a cause of secondary osteoporosis.
Faiman B, Licata AA.
Cleve Clin J Med. 2010;77(4):273-8.
Most patients with multiple myeloma or other monoclonal gammopathies present with anemia, hypercalcemia, or renal insufficiency.
19205951
MALE Middle Aged
Effects of hemodialysis on profound memory deficits in renal insufficiency due to multiple myeloma: a case study.
Plagge JM, Clay JE, Redwine RL, LePage JP.
Appl Neuropsychol. 2009;16(1):76-82.
Effects of hemodialysis on profound memory deficits in renal insufficiency due to multiple myeloma: a case study.
19205951
MALE Middle Aged
Effects of hemodialysis on profound memory deficits in renal insufficiency due to multiple myeloma: a case study.
Plagge JM, Clay JE, Redwine RL, LePage JP.
Appl Neuropsychol. 2009;16(1):76-82.
We present a complex case of an individual with multiple myeloma, renal insufficiency, treated seizure disorder, and schizophrenia, paranoid type, who experienced functional improvements in memory and visuospatial function with short- and long-term administration of hemodialysis.
18452093
MIXED_SAMPLE Adult
Azotemia associated with use of lenalidomide in plasma cell dyscrasias.
Batts ED, Sanchorawala V, Hegerfeldt Y, Lazarus HM.
Leuk Lymphoma. 2008;49(6):1108-15.
We describe five patients with plasma cell dyscrasias and renal insufficiency (AL amyloidosis, monoclonal gammopathy of undetermined significance with Fanconi syndrome, and multiple myeloma) treated with lenalidomide and dexamethasone who developed progressive azotemia.
18627621
(2500028)
OTHER
Multiple myeloma presenting with high-output heart failure and improving with anti-angiogenesis therapy: two case reports and a review of the literature.
Robin J, Fintel B, Pikovskaya O, Davidson C, Cilley J, Flaherty J.
J Med Case Rep. 2008;2:229.
Common manifestations of multiple myeloma include osteolytic lesions, cytopenias, hypercalcemia, and renal insufficiency.
17645096
MALE Middle Aged
[Prostate adenocarcinoma and synchcronous multiple myeloma: a case report].
Perez Lopez ME, Garcia Mata J, Garcia Gomez J, Salgado Fernandez M, Firvida Perez JL.
Actas Urol Esp. 2007;31(2):157-9.
The presence of multiple myeloma must be to rule out when there are bone lytics injuries, well biochemical evolution with therapy and clinical deterioration, hypercalcemia and quickly progressive renal insufficiency.
16880241
MALE Middle Aged
Primary (AL) amyloidosis in plasma cell disorders.
Muller AM, Geibel A, Neumann HP, Kuhnemund A, Schmitt-Graff A, Bohm J, Engelhardt M.
Oncologist. 2006;11(7):824-30.
Here, we present a 46-year-old man with an exceptional clinical course of an LC multiple myeloma with generalized amyloidosis, causing renal insufficiency, congestive heart failure, and complete intestinal necrosis.
17086151
MALE Middle Aged
[Amyloid cardiomyopathy: A rare cause of cerebral embolism].
Saux A, Heroum C, Sportouch C, De Graeve F, Lequellec A, Pages M.
Rev Neurol (Paris). 2006;162(11):1128-30.
Echocardiography was suggestive of an amyloid cardiopathy, and an IgG lambda multiple myeloma with renal insufficiency was discovered.
16335310
MALE
[Painful shoulder in the elderly--not always of degenerative nature].
Scharer M, Taverna C, Schulthess G.
Praxis (Bern 1994). 2005;94(47):1863-8.
Diagnosis of multiple myeloma requires monoclonal protein (paraprotein) in the serum or urine, plasma cell infiltration of the bone marrow, and evidence of end-organ damage (anemia, renal insufficiency, bone lesions or hypercalcemia).
11722600
FEMALE
Is there any significance for intracellular crystals in plasma cells from patients with monoclonal gammopathies?
Gardais J, Genevieve F, Foussard C, Delisle V, Zandecki M.
Eur J Haematol. 2001;67(2):119-22.
We report one case of indolent kappa-chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer-rod-like intracytoplasmic inclusions.
10692294
MALE Middle Aged
Disappearance of nodular mesangial lesions in a patient with light chain nephropathy after long-term chemotherapy.
Komatsuda A, Wakui H, Ohtani H, Kodama T, Miki K, Imai H, Miura AB.
Am J Kidney Dis. 2000;35(3):E9.
A 64-year-old man developed multiple myeloma (kappa light chain type), nephrotic syndrome, and renal insufficiency in 1993.
11086485
FEMALE
[Renal insufficiency due to light chain multiple myeloma].
van Zaanen HC, Diderich PP, Pegels JG, Ruizeveld de Winter JA.
Ned Tijdschr Geneeskd. 2000;144(45):2133-7.
[Renal insufficiency due to light chain multiple myeloma].
10348151
MALE Middle Aged
Effect of high-dose melphalan and peripheral blood stem cell transplantation on renal function in patients with multiple myeloma and renal insufficiency: a case report and review of the literature.
Reiter E, Kalhs P, Keil F, Rabitsch W, Gisslinger H, Mayer G, Worel N, Lechner K, Greinix HT.
Ann Hematol. 1999;78(4):189-91.
Effect of high-dose melphalan and peripheral blood stem cell transplantation on renal function in patients with multiple myeloma and renal insufficiency: a case report and review of the literature.
9747478
MALE
Multiple myeloma presenting with external ear canal mass.
Quinodoz D, Dulguerov P, Kurt AM, Ruefenacht D, Abele R, Allal AS, Montandon P.
J Laryngol Otol. 1998;112(5):469-71.
The manifestations of multiple myeloma are protean and related to bony osteolytic lesions, and to medullar and renal insufficiency.