Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Nephropathy

A nonspecific term referring to disease or damage of the kidneys.


Total: 56

                       


(per page)
PMID (PMCID)
30799965
 OTHER
Waldenstrom Macroglobulinemia: Unusual Presentation With Cast Nephropathy/Light Chain Tubulopathy.
Ashraf M, Rastogi P.
Clin Med Insights Case Rep. 2019;12:1179547619828704.
Cast Nephropathy/Light chain tubulopathy is usually present in patients with multiple myeloma and is very rare in patients with Waldenstrom Macroglobulinemia.
30311522
 OTHER
kappa Light-chain monoclonal gammopathy and cast nephropathy in a horse with multiple myeloma.
Eberhardt C, Malbon A, Riond B, Schoster A.
J Am Vet Med Assoc. 2018;253(9):1177-1183.
954 Light-chain monoclonal gammopathy and cast nephropathy in a horse with multiple myeloma.
28545410
(5445476)
 MALE Middle Aged
Combined proximal tubulopathy, crystal-storing histiocytosis, and cast nephropathy in a patient with light chain multiple myeloma.
Wu CK, Yang AH, Lai HC, Lin BS.
BMC Nephrol. 2017;18(1):170.
To the best of our knowledge, this is the first report of simultaneous light chain proximal tubulopathy, crystal-storing histiocytosis, and myeloma cast nephropathy in 954 light chain multiple myeloma.
28545410
(5445476)
 MALE Middle Aged
Combined proximal tubulopathy, crystal-storing histiocytosis, and cast nephropathy in a patient with light chain multiple myeloma.
Wu CK, Yang AH, Lai HC, Lin BS.
BMC Nephrol. 2017;18(1):170.
We present a case report of a rare simultaneous occurrence of light chain proximal tubulopathy, crystal-storing histiocytosis, and myeloma cast nephropathy in a patient with 954 light chain multiple myeloma.
28545410
(5445476)
 MALE Middle Aged
Combined proximal tubulopathy, crystal-storing histiocytosis, and cast nephropathy in a patient with light chain multiple myeloma.
Wu CK, Yang AH, Lai HC, Lin BS.
BMC Nephrol. 2017;18(1):170.
Combined proximal tubulopathy, crystal-storing histiocytosis, and cast nephropathy in a patient with light chain multiple myeloma.
28540855
 MIXED_SAMPLE Adult
Interest of the combined measurement of selected urinary proteins in the diagnosis approach in nephrology.
Bastard JP, Fellahi S, Lescure FX, Capeau J, Ronco P, Plaisier E.
Ann Biol Clin (Paris). 2017;75(3):327-333.
Two cases illustrate two distinct clinical situations in patients with multiple myeloma, respectively myeloma cast nephropathy and toxic acute tubular necrosis.
27504298
 OTHER
Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy.
Grover S, Selhi PK, Sood N, Sandhu JS, Kaur H.
J Clin Diagn Res. 2016;10(6):ED04-5.
Multiple myeloma is a disorder of plasma cells which can involve kidneys in the form of cast nephropathy.
27504298
 OTHER
Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy.
Grover S, Selhi PK, Sood N, Sandhu JS, Kaur H.
J Clin Diagn Res. 2016;10(6):ED04-5.
Acute renal failure due to cast nephropathy can rarely be the first presentation of multiple myeloma.
27014760
 FEMALE
Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review.
Brilland B, Sayegh J, Croue A, Bridoux F, Subra JF, Augusto JF.
J Gastrointestin Liver Dis. 2016;25(1):99-103.
We report the case of a 66-year-old female with 954-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver 954-light chain deposition.
26354571
 MALE Middle Aged
A case of primary renal allograft dysfunction due to myeloma cast nephropathy.
Lingaraj U, Vankalakunti M, Radhakrishnan H, Sreedhara CG, Rajanna S.
Saudi J Kidney Dis Transpl. 2015;26(5):970-5.
We report a rare case of primary renal allograft dysfunction due to myeloma cast nephropathy in a patient with no overt clinical features of multiple myeloma preceding his transplantation.
26354571
 MALE Middle Aged
A case of primary renal allograft dysfunction due to myeloma cast nephropathy.
Lingaraj U, Vankalakunti M, Radhakrishnan H, Sreedhara CG, Rajanna S.
Saudi J Kidney Dis Transpl. 2015;26(5):970-5.
This is probably the first report of primary renal allograft dysfunction due to myeloma cast nephropathy diagnosed within the first week post-transplanation in a patient with unrecognized multiple myeloma.
26458669
 MALE Middle Aged
Immunoglobulin G kappa biclonal gammopathy associated with multiple myeloma, plasmacytoma and cast nephropathy.
Pradhan D, Arora P, Gami A, Kaur N.
J Cancer Res Ther. 2015;11(3):660.
Immunoglobulin G kappa biclonal gammopathy associated with multiple myeloma, plasmacytoma and cast nephropathy.
25838654
(4379621)
 OTHER
Light chain proximal tubulopathy with cast nephropathy in a case of multiple myeloma.
Gowda KK, Joshi K, Nada R, Ramachandran R, Sachdeva M.
Indian J Nephrol. 2015;25(2):119-22.
Light chain proximal tubulopathy with cast nephropathy in a case of multiple myeloma.
26631886
 MALE
Rapid Deterioration of the Renal Function Caused by the Coexistence of Intratubular Amyloidosis and Myeloma Cast Nephropathy.
Kato H, Fujigaki Y, Asakawa S, Yamaguchi Y, Uozaki H, Komatsuda A, Nagata M, Uchida S.
Intern Med. 2015;54(23):3023-8.
We herein present a rare case with rapid progression of renal failure caused by the co-occurrence of intratubular amyloidosis and cast nephropathy due to multiple myeloma.
26631886
 MALE
Rapid Deterioration of the Renal Function Caused by the Coexistence of Intratubular Amyloidosis and Myeloma Cast Nephropathy.
Kato H, Fujigaki Y, Asakawa S, Yamaguchi Y, Uozaki H, Komatsuda A, Nagata M, Uchida S.
Intern Med. 2015;54(23):3023-8.
Multiple myeloma presents with various kidney injuries, including cast nephropathy, light chain deposition disease, and amyloidosis.
24429451
 MALE
Acquired Fanconi syndrome with proximal tubular cytoplasmic fibrillary inclusions of lamda light chain restriction.
Yao Y, Wang SX, Zhang YK, Wang Y, Liu L, Liu G.
Intern Med. 2014;53(2):121-4.
We herein present a case of multiple myeloma with Fanconi syndrome and acute kidney injury due to light chain proximal tubulopathy with light chain cast nephropathy.
25308025
 MALE Middle Aged
Unique morphology of intratubular light chain casts in multiple myeloma: the amyloid cast nephropathy.
Sharma A, Bansal S, Jain R.
Indian J Pathol Microbiol. 2014;57(4):629-31.
Unique morphology of intratubular light chain casts in multiple myeloma: the amyloid cast nephropathy.
25308025
 MALE Middle Aged
Unique morphology of intratubular light chain casts in multiple myeloma: the amyloid cast nephropathy.
Sharma A, Bansal S, Jain R.
Indian J Pathol Microbiol. 2014;57(4):629-31.
Cast nephropathy is the most frequent pattern of renal involvement in multiple myeloma characterized by presence of tubular casts with characteristic morphology that are composed of monotypic (either kappa or lambda) light chains as seen by immunofluorescence microscopy.
23350020
(3552781)
 OTHER
Early Application of High Cut-Off Haemodialysis for de-Novo Myeloma Nephropathy is Associated with Long-Term Dialysis-Independency and Renal Recovery.
Khalafallah AA, Loi SW, Love S, Mohamed M, Mace R, Khalil R, Girgs M, Raj R, Mathew M.
Mediterr J Hematol Infect Dis. 2013;5(1):e2013007.
Multiple myeloma (MM) is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC).
22541683
 MALE Middle Aged
Recovery of kidney function following delayed use of Theralite™ dialyzer in a patient with myeloma cast nephropathy.
Dahal K, Shastri S, Narayanasami U, Bijol V, Rider K, Strom JA, Jaber BL.
Clin Nephrol. 2013;79(4):318-22.
We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy.