Multiple myeloma

Multiple myeloma (MM) is a malignant tumor of plasma cell characterized by overproduction of abnormal plasma cells in the bone marrow and skeletal destruction. The clinical features are bone pain, renal impairment, immunodeficiency, anemia and presence of abnormal immunoglobulins (Ig).

Progressive visual loss

A reduction of previously attained ability to see.


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PMID (PMCID)
18347452
 MALE
Histopathologic features of multiple myeloma involving the optic nerves.
Yeung SN, Paton KE, Dorovini-Zis K, Chew JB, White VA.
J Neuroophthalmol. 2008;28(1):12-6.
We report a case of optic nerve involvement by multiple myeloma in which progressive visual loss heralded leukemic transformation and intracranial involvement.
9932972
 FEMALE Middle Aged
Bilateral optic neuropathy with IgGkappa multiple myeloma improved after myeloablative chemotherapy.
Lieberman FS, Odel J, Hirsh J, Heinemann M, Michaeli J, Posner J.
Neurology. 1999;52(2):414-6.
A 49-year-old woman with immunoglobulin GK multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas.